从普通肝素到磺达肝癸钠——肝素类抗凝药物研发历程精选.pptVIP

* 抗Xa活性对分子量不敏感，抗IIa活性依赖分子量。分子量越大，抗IIa活性越强。 * Permission needed. * Permission needed. * 肝素与PF4结合形成复合体，此复合体再会结合IgG形成了HIT抗体，HIT抗体通过IgG与血小板相结合，从而造成了血小板与血小板之间的聚集。由此引起血小板减少症以及血栓形成。 * Although fondaparinux does not mediate the inhibition of coagulation factors other than factor Xa, it inhibits thrombin generation in a dose-dependent manner, whether triggered via the extrinsic or intrinsic pathway, and in the absence or presence of platelets.1-3 This last finding, which may reflect the lack of sensitivity of fondaparinux to inactivation by platelet-released heparin-neutralising proteins such as plate