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(4) Superinfection in the course of prolonged chemotherapy. (5) Emergence of drug-resistant organisms. (6) Participation of two or more microorganisms in the infectious process, of which only one was originally detected and used for drug selection. (7) Inadequate host defenses, including immunodeficiencies and diabetes. (8) Noninfectious causes, including drug fever, malignancy, and autoimmune disease. * Strategies stopping the increase of antimicrobial resistance R G P Decrease the Antimicrobial resistance Governments intervention Medical staff， Avoid overu