浙江大学研究生免疫学英文课件CD CAM细胞间粘附分子.ppt

Others: PD-1 (CD28 family member) B7-H1 CD45 (leukocyte common antigen, LCA) CD45RA+ na?ve T cell CD45RO+ memory T cell BCR/CD79a/CD79b CD19 CD21 CD81 co-stimulatory molecules CD40 (B、DC) CD154 ( CD4+ T) CD20 Rituximab（中文名：美罗华） * * * * * * * * * * * * CAMs and CD molecules are respectively designated according to the different aspects of these molecules. CAMs are grouped depending on their adhesion functions. CD molecules contain the majority of CAMs that have obtained CD designation. A minority of CAMs have not been given CD designation. CAMs and CD molecules are respectively designated according to the different aspects of these molecules. CAMs are grouped depending on their adhesion functions. CD molecules contain the majority of CAMs that have obtained CD designation. A minority of CAMs have not been given CD designation. Categories of CAM 1. Integrin family 2. Selectin family 3. Cadherin 4. IGSF (immunoglobulin superfamily) 5. Mucin-like vascular addressin family 6. Others: PNAd, CD44, CD36 Integrin Integrin family is so named because the molecules of this family primarily mediate the cellular adherence to extracellular matrix, enabling cells and extracellular matrix to form the integration. 1. Structure: Heterodimeric proteins consisting of two non-covalently bound polypeptides (? and ? chains). 2. Components of integrin family ?1: VLA (very late appearing antigen) ?2: LFA-1 (lymphocyte function associated antigen-1); ligand: ICAM-1 ?3: gpIIb 3. Distribution Broad distribution on the surface of cells. Integrin Selectin family 1. Structure Transmembrane glycoproteins, with a number of extracellular domains homologous to those seen in complement control proteins (CCP). The extracellular region also contains a domain related to the EGF receptor and a distal C type lectin-like domain. 2. Members of selectin family L-selectin(CD62L): leukocytes P-selectin(CD62P): platelets and megakaryocytes