原创力文档discovery of n-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (chmfl-btk-01) as a highly selective irrevers：（发现n -(3 -(5 -((3-acrylamido-4 -(morphol）.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
discovery of n-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (chmfl-btk-01) as a highly selective irrevers：（发现n -(3 -(5 -((3-acrylamido-4 -(morphol）
European Journal of Medicinal Chemistry 131 (2017) 107e125
Contents lists available at ScienceDirect
European Journal of Medicinal Chemistry
journal homepage: /locate/ejmech
Research paper
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)
phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-
methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly
selective irreversible Brutons tyrosine kinase (BTK) inhibitor
a, b, 1 b, c, 1 b, d, 1 b, c, 1
Qianmao Liang , Yongfei Chen , Kailin Yu , Cheng Chen ,
e, 1 b, d b, c b, d a, b
Shouxiang Zhang , Aoli Wang , Wei Wang , Hong Wu , Xiaochuan Liu ,
Beilei Wang b, c, Li Wang b, c, Zhenquan Hu b, c, Wenchao Wang b, c, Tao Ren f,
Shanchun Zhang c, g, Qingsong Liu b, c, d, f, Cai-Hong Yun e, *, Jing Liu b, c, **
a Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230036, PR China
b High Magnetic Field Laboratory, Chinese Academy of Sciences, Mailbox 1110, 350 Shushanhu Road, Hefei, Anhui 230031, PR China
c CHMFL-HCMTC Target Therapy Joint Laboratory, 350 Shushanhu Road, Hefei, Anhui 230031, PR China
d University of Science and Technology of China, Hefei, Anhui 230036, PR China
e Institute of Systems Biomedicine, Department of Biophysics, Beijing Key Laboratory of Tumor Systems Biology and Center for Molecular and Translational
Medicine, School of Basic Medical Sciences, Peking University Health
您可能关注的文档
- Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme：（发现deoxyvasicinone衍生品作为NEDD8-activating酶的抑制剂）.pdf
- Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking：（发现fragment-based BRD4 bromodomain抑制剂的高通量对接）.pdf
- discovery of highly reactive peptide tag by elisa-type screening for specific cysteine conjugation：（发现高活性肽标签elisa-type筛查特定的半胱氨酸接合）.pdf
- discovery of highly conserved unique peanut and tree nut peptides by lc–msms for multi-allergen detection：（发现树高度保守的独特的花生和坚果肽信用证）.pdf
- discovery of host-targeted covalent inhibitors of dengue virus：（登革热病毒的发现host-targeted共价抑制剂）.pdf
- discovery of diverse and functional antibodies from large human repertoire antibody libraries：（人类发现的多样化和功能抗体从大型曲目抗体库）.pdf
- discovery of discriminatory quality control markers for chinese herbal medicines and related processed products by combination of chromatographic analysis and chemometrics methods radix scutellariae a：（发现歧视中国中药质量控制指标和相关加工产品的组合色谱分析和化学计量学方法黄芩）.pdf
- discovery of furan carboxylate derivatives as novel inhibitors of atp-citrate lyase via virtual high-throughput screening：（发现呋喃羧酸盐衍生物新型抑制剂的atp柠檬酸裂解酶通过虚拟大规模筛选）.pdf
- discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under dmso-perturbed assay conditions：（透明质酸酶抑制剂的发现来自天然产物及其dmso-perturbed试验条件下的机械特性）.pdf
- discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood：（发现成人海马神经发生基于有效刺激器支架在龙的血液）.pdf
- discovery of nanomolar ligands with novel scaffolds for the histamine h4 receptor by virtual screening：（发现摩尔配体的新型支架组胺h4受体通过虚拟筛选）.pdf
- discovery of new mura inhibitors using induced-fit simulation and docking：（新发现的色差抑制剂使用诱导契合模拟和对接）.pdf
- discovery of n-substituted-endo-3-(8-aza-bicyclo[3.2.1]oct-3-yl)-phenol and -phenyl carboxamide series of μ-opioid receptor antagonists：（发现n-substituted-endo-3(8-aza-bicyclo[3.2.1]oct-3-yl)苯酚和苯甲酰胺系列的）.pdf
- discovery of phenyl acetamides as potent and selective gpr119 agonists：（发现苯乙酰胺有效和选择性gpr119受体激动剂）.pdf
- discovery of potent n-(isoxazol-5-yl)amides as hsp90 inhibitors：（发现强有力的n -(isoxazol-5-yl)酰胺一半抑制剂）.pdf
- discovery of potent and efficacious pyrrolopyridazines as dual jak13 inhibitors：（发现有力和有效的pyrrolopyridazines双重jak13抑制剂）.pdf
- discovery of potent α1l-adrenoceptor agonists design and synthesis of bicyclic derivatives：（发现的）.pdf
- discovery of potent, reversible metap2 inhibitors via fragment based drug discovery and structure based drug design—part 2：（发现的,可逆metap2抑制剂通过基于片段的药物发现和基于结构的药物设计）.pdf
- discovery of orally active hepatoselective glucokinase activators for treatment of type ii diabetes mellitus：（发现口服hepatoselective葡糖激酶活化剂治疗ii型糖尿病）.pdf
- discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance：（发现潜在的抗癌多靶向川芎嗪环己酮和肟类似物克服肿瘤多药耐药性）.pdf
文档评论（0）