drug discovery targeting heme-based sensors and their coupled activities：（药物发现针对heme-based传感器及其耦合活动）.pdfVIP

Journal of Inorganic Biochemistry 167 (2017) 12 –20 Contents lists available at ScienceDirect Journal of Inorganic Biochemistry j ournal homepage : www.el /l oca te/jinorgbio Focused review Drug discovery targeting heme-based sensors and their coupled activities Eduardo Henrique Silva Sousa a,⁎, Luiz Gonzaga de França Lopes a, Gonzalo Gonzalez b, Marie-Alda Gilles-Gonzalez b a Laboratory of Bioinorganic Chemistry, Department of Organic and Inorganic Chemistry, Federal University of Ceara, Center for Sciences, Fortaleza, Ceara 60440-900, Brazil b Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038, USA a r t i c l e i n f o a b s t r a c t Article history: Heme-based sensors have emerged during the last 20 years as being a large family of proteins that occur in all Received 10 August 2016 kingdoms of life. A myriad of biological adaptations are associated with these sensors, which include vasodilation, Received in revised form 8 November 2016 bacterial virulence, dormancy, chemotaxis, biofilm formation, among others. Due to the key activities regulated Accepted 16 November 2016 by these proteins along with many other systems that use similar output domains, there is a growing interest Available online 20 November 2016 in developing small molecules as their regulators. Here, we review the development of potential activators and inhibitors for many o