drug discovery through stem cell-based organoid models：（通过干细胞瀑样模型药物发现）.pdfVIP

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drug discovery through stem cell-based organoid models：（通过干细胞瀑样模型药物发现）.pdf

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drug discovery through stem cell-based organoid models：（通过干细胞瀑样模型药物发现）

Advanced Drug Delivery Reviews 69–70 (2014) 19–28 Contents lists available at ScienceDirect Advanced Drug Delivery Reviews journa l h omepage: /locate/addr ☆ Drug discovery through stem cell-based organoid models Adrian Ranga, Nikolche Gjorevski, Matthias P. Lutolf ⁎ Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland a r t i c l e i n f o a b s t r a c t Available online 26 February 2014 The development of new drugs is currently a long and costly process in large part due to the failure of promising drug candidates identiﬁed in initial in vitro screens to perform as intended in vivo. New approaches to drug Keywords: screening are being developed which focus on providing more biomimetic platforms. This review surveys this Stem cell new generation of drug screening technologies, and provides an overview of recent developments in organoid Organoid culture systems which could afford previously unmatched ﬁdelity for testing bioactivity and toxicity. The chal- High-throughput screening lenges inherent in such approaches will also be discussed, with a view towards bridging the gap between Drug disc