紫菜多肽降血脂及抗氧化作用研究_王茵苏永昌吴靖娜刘淑集吴成业.pdf

网络出版时间：2013-04-25 09:09 网络出版地址：/kcms/detail/11.1759.TS0909.003.html 紫菜多肽降血脂及抗氧化作用研究1 王茵 苏永昌 吴靖娜 刘淑集 吴成业* （福建省水产研究所，福建厦门 361012） 摘要：为探讨紫菜多肽的血脂调节和抗氧化作用，本研究通过动物实验，建立高血脂大鼠模型，比较分析 紫菜多肽对高血脂大鼠体质量、肝脏系数、血脂指标及过氧化指标的影响情况。结果显示，紫菜多肽各剂 量组大鼠的体质量增加幅度较高脂模型组有显著下降；血清TC、TG 和LDL-C 含量降低，HDL-C 含量升 高，综合表现为AI 降低；血清中GSH-Px 和SOD 活性升高，MDA 含量降低；肝脏组织中GSH-Px 活性升 高，MDA 含量降低，但肝脏系数和SOD 活性变化不大。研究表明，紫菜多肽能有效控制高血脂模型大鼠 体质量的增加，改善血脂水平，提高抗氧化酶活力，抑制脂质过氧化反应，降低患动脉硬化疾病的风险。 关键词：紫菜多肽 降血脂 抗氧化 动物实验 中图分类号：R965 文献标识码：A Experimental study on the Hypolipidemic Effect and Antioxidative Activity of Porphyra Peptide Wang Yin, Su Yongchang, Wu Jingna, Liu shuji, Wu Chengye Fisheries Research Institute of Fujian，Xiamen 361012 Abstract : To study the hypolipidemic effects and antioxidation of porphyra peptide, hyperlipidemic rats were induced to analyze the hypolipidemic effects and antioxidant of porphyra peptide on weights, liver coefficient, lipid index and antioxidative index in hyperlipidemic rate. The results showed that a significant reduction on weight gain in the groups with different doses of porphyra peptide . The serum TC, TG and LDL-C were decreased while HDL-C was elevated, which showed a lower AI. The activity of serum GSH-Px and SOD were higher, while MDA was lower, but liver coefficient and SOD activity remained. In conclusion, porphyra peptide have obvious effects on controlling weight gain, improving lipid index, increasing antioxidase activity, inhibiting of lipid peroxida