【医学课件】 GI Physiology Module Absorption of Water and Ions.pptVIP

GI Physiology Module:Absorption of Water and Ions;NASPGHAN Physiology Education Series;Objectives;Key Concepts: GI Fluid and Electrolyte Balance;Intestinal Epithelial Cells as Gatekeepers for Ion and Fluid Movement;Tight Junctions;Transepithelial Transport: Transcellular ;Mechanisms of Transcellular Transport;Overview of fluid movement in the GI tract;Anatomic Considerations;Gut Surface Area Amplification;Location – Based Specialization within the Gut;Simultaneous secretion and absorption occur in any segment of the intestine;Small Intestinal Ion Transport Mechanisms;Colonic ion transport mechanisms;Cellular Basis of Transport;Concept 1: Na, K ATPase;Concept 2: Na Coupled Transport;Clinical Application: Oral Rehydration Solution;Concept 3: NaCl Co-transport is mediated by TWO transport proteins;Concept 4: Chloride secretion occurs in conjunction with basolateral Na, K, Cl transport;Concept 5: Water follows NaCl;Absorption and Secretion in Health versus Diarrheal States;Multiple Systems Interact in Regulation of Ion Transport and Secretion;Multiple Systems Interact in Regulation of Ion Transport and Secretion;Mechanisms of Diarrhea: Osmotic versus Secretory;Mechanisms of Bacterial Pathogens;cAMP and Chloride secretion;Pathogenesis of Cholera;CFTR mutation and cholera;Minerals and Vitamins;~ 2000mg;;Calcium and Magnesium Absorption;Water Soluble Vitamins;Fat Soluble Vitamins;Soden: Seminars in Ped Surgery 2010;Summary;Please send any questions or comments to ? ? ?Christine.Waasdorp@childrenscolorado.org? ?Daniel.Kamin@childrens.harvard.edu