青霉素简介(英文课件)Production of penicillin.pptVIP

Production of penicillin;Downstream Processing;Antibiotics are antimicrobial agents produced naturally by other microbes (usually fungi or bacteria). The first antibiotic was discovered in 1896 by Ernest Duchesne and rediscovered byAlexander Flemming in 1928 from the filamentous fungus Penicilium notatum. ;;When penicillin was first made at the end of the second world war using the fungus Penicilium notatum, the process made 1 mg dm-3. Today, using a different species (P. chrysogenum) and a better extraction procedures the yield is 50 g dm-3. There is a constant search to improve the yield.