(精选)【医学课件课件】 甲状腺激素和抗甲状腺药教学课件.pptVIP

甲状腺激素和抗甲状腺药Thyroid hormones and antithyroid drugs;Summary Thyroid hormones Necessary to maintain normal metabolism, growth and development. Hypothyroidism Cause Cretinism if it happens in embryo or neonatal period. Cause myxedema if it happens in adults when the thyroid hormone could be used in replacement therapy. Hyperthyroidism A syndrom characterized by thyroid oversecretion and metabolic disorder caused by multiple reasons. It can be treated with radioactive iodine (131I) irradation, antithyroid drugs and operation. ;Thyroid hormones;抗甲状腺药;硫脲类;Thyroid hormones are iodic amino acids Active components Thyroxine, T4 Triiodothyreninum natricum, T3 Chemical constitution;甲状腺激素的化学结构;Physiological disposition of thyroid hormones;Synthesis, storage and release of thyroid hormone;Thyroid hormones;Mechanism of action（figure) It is believed now that the thermogenic action of T3 and T4 is due to the increase of sodium pumps activity on the cell membrane . Na+,K+—ATPase activity ATP utilization ADP concentration mitochondria respiration oxide consumption and heat production ;Physiological and pharmacological actions;Thyroid clinical application;Adverse effects;Antithyroid Drugs;硫脲类;Thiourea;Pharmacological actions Inhibit peroxydase in adenocytes , which results in the inhibited oxydation of I－ to I0 . Then , the iodation and couple of tyrosines can be stopped . So the biosynthesis of T3 and T4 is inhibited. But the effect occurs slowly as the iodine uptake and the hormone already synthesized are not effected. Long time medication can lead to decrease of T3 and T4, which feedback increases the secretion of TSH and makes thyroid hyperplasy and hyperemic compensatorily. Propylthiouracil can inhibit T4 turning to T3 and control T3 level in blood . So it is the first choice in hyperthyroidism crisis, severe hyperthyroidism and pregnant hyperthyroidism. Inhibit immuno-system (as hyperthyroidism is related with abnormal immunoreacti