(精选)Therapies targeting the immune system教学课件.pptVIP

Neuroimmunological diseases : diseases with demyelination - inhibiting complement effect MS (?) Primairy immunodefficiencies: Ig 400 mg/dl Idiopathic trombocytopenia purpura: low platelet number - IVIG inhibits phagocytosis CLL: against bacterial infections infectious diseases, toxic shock (100 000/year) –sepsis Kawasaki disease: chronic vasculitis - IVIG – neutralization effect , IVIG therapy - examples Intravenous Ig therapy, (IVIG) Immunmodulatory, anti-inflammatory effect α2,6 SA containing IVIG antiinflammatory effect - model α2,6 sialyc acid recognizing receptor : SIGN-R, human:DC-SIGN Anthony and Ravetch, J CLin Immunol. 2010.30 suppl. S9-S14 IMMUNSUPPRESSION Block unwanted immunoresponse: - Allergy - Autoimmune diseases - transplantation: rejection, GVH Antigen specific immunsuppression – aim: to induce specific tolerance a, Antigen-specific (pl. oral tolerance) b, Non-antigen specific corticosteroids CY-A, FK 506, Rapamycin, irradiation Cytostatic agents Antigen non-specific immunosuppression: Corticosteroids Inhibit inflammation Mechanisms: they act via hormon receptors Naturally occuring 21 C atoms steroid hormon: Corticosteroid ? product of cholesterin metabolism 1948: hydrocortison (Reumatoid arthritis) O OH O O O O cortison prednison (4x more efficient) cortisol prednisolon synthetic products: structure: CH2OH C=O OH CH2OH C=O OH CH2OH C=O OH CH2OH C=O OH The structure of the anti-inflammatory corticosteroid drug prednisone Prednisone is a synthetic analogue of the natural adrenocorticosteroid cortisol. Introduction of the 1,2 double bond into the A ring increases anti-inflammatory potency approximately fourfold compared with cortisol, without modifying the sodium-retaining activity of the compound steroid steroid receptor HSP-90 nucleus cell membrane Mechanism of action regulatory gene element transcription mRNA translation