A STUDY ON PHARMACODYNAMIC DRUG INTERACTION OF ：在药效学相互作用的研究.docVIP

A STUDY ON PHARMACODYNAMIC DRUG INTERACTION OF ESOMEPRAZOLE AND ANTIDIABETIC DRUGSS. Protocol of Dissertation Submitted By Mr. PRASHANT DNYANDEO PHADATARE. To RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES BANGALORE, KARNATAKA. Under the guidance of Mr. CHANDRASHEKHAR V.M. Assist. Professor (2008-2009) Department of Pharmacology, HANAGAL SHRI KUMARESHWAR COLLEGE OF PHARMACY, BAGALKOT- 587101, KARNATAKA RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES BANGALORE, KARNATAKA ANNEXURE II PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERATATION 1. Name of the Candidate and Address PRASHANT DNYANDEO PHADATARE. DEPARTMENT OF PHARMACOLOGY, H.S.K.COLLEGE OF PHARMACY, B.V.V.S. CAMPUS, BAGALKOT-587101. KARNATAKA. 2. Name of the Institution H.S.K.COLLEGE OF PHARMACY, B.V.V.S.CAMPUS, BAGALKOT-587101. KARNATAKA. 3. Course of Study and Subject MASTER OF PHARMACY IN PHARMACOLOGY 4. Date of admission to Course 17-O7-2008 5. Title of the topic: “A STUDY ON PHARMACODYNAMIC DRUG INTERACTION OF ESOMEPRAZOLE AND ANTIDIABETIC DRUGS” 6. Brief resume of the intended work 6.1 Need for the study: Drug interaction can be defined as the modification of the effect of one drug by the prior or concomitant administration of another drug. The more drugs a patient takes the greater the likelihood that an adverse reaction will occur. One hospital study found that the rate was 7 % in those taking 6 to 10 drugs, but 40% in those taking 16 to 20 drugs which represents a disproportionate increase1.According to one report , the drug interaction may be fourth to sixth leading cause of death in united sates2. Recent studies have demonstrated that may patient receive multiple drug therapy with recognize potential. When patient has subjected various therapeutics regimen increases, the greater is the risk of occurrence of drug interaction3.This may lead to enhanced or diminished effect and may be useful or harmful. The responsible position lies between these two extremes because