生理学11鼓楼医院-朱大龙会议-内分泌与代谢幻灯片.pptVIP

Males Females 4 week of treatment Nuclear magnetic resonance imaging 1 day of treatment Diet-induced thermogenesis Estrogen mimics leptin’s effect on the rewiring of POMC cells independently of leptin receptor-mediated signaling Leptin signaling E2, Peptide Hormone, Nutrition factors and Environmental inputs Transmitters POMC, NPY Synaptic plasticity ?? Behavioral adaptations Cellular adaptations Food intake Energy expenditure ?? P-Stat3 was induced by estrogen in mouse hypothalamus Estrogen: 10ug/mouse in 500ul saline. b-actin STAT3 pSTAT3 0 15 30 60 90 120