生统课件2016SurvivalAnalysis-Lecture幻灯片.pptVIP

Comparing 2 groups Use log-rank test to test the null hypothesis of no difference between survival functions of the two groups (more on this next time) * One problem Survival estimates can be unreliable toward the end of a study when there are small numbers of subjects at risk of having an event. WHI and breast cancer Small numbers left Women’s Health Initiative Writing Group. JAMA.?2002;288:321-333. * Limitations of Kaplan-Meier Mainly descriptive No control for covariates Require categorical predictors Unable to accommodate time-dependent variables * * Draw schematic of temporality. * 1.