抗生素的将来？(英文教学)What future for antibiotics？典型实例.pptVIP

What future for antibiotics?;The pre-antimicrobial era;Milestones in antimicrobial chemotherapy;Milestones in antimicrobial chemotherapy;Antibiotic targets;Beta-lactams and glycopeptides inhibit peptidoglycan synthesis;b-Lactams - mode of action;“…that we had essentially defeated infectious diseases and could close the book on them…” US Surgeon General, William H. Stewart [1969]; ;Emergence of antibiotic resistance by selective pressure;Hospital-acquired infections to drug-resistant bacteria (USA 2002);;MRSA in Europe (2002 data);Antibiotics – mechanisms of resistance;Resistance to antibacterial agents;b-lactam antibiotics andb-lactamase;-;b-lactamase inhibitors;Altered penicillin-binding proteins (PBPs);Glycopeptides block carboxypeptidase/transpeptidase;Glycopeptide resistance;Glycopeptide resistance;Resistance by efflux pumps; Efficacious clinical introductions need to keep pace with the erosion of the current antibacterial armamentarium;Keeping up with resistance?;The search for new agents;Are there more targets for antibiotics?;The promise of ‘…omics’?;Search in Salmonella;Shortage of new targets;RNA interference;Platensimycin and fatty acid biosynthesis;Platensimycin and fatty acid biosynthesis;Enzybiotics;Modify but don’t kill – a novel approach?; ;Modification of phenotype: ‘reducing fitness’;Components of Japanese green tea modify resistance to key antibiotics ;0.5;Antibiotics in 2006