肿瘤疫苗的分子设计一总结概括.pptVIP

肿瘤疫苗的分子设计;Chapter VIII;;Angiogenesis in Breast Cancer ;第一节 肿瘤和宿主免疫系统间的相互作用;Escape from immuno-surveillance;Tumor escape mechanisms;一、肿瘤诱发的细胞因子和免疫抑制;表 -1 免疫抑制性细胞因子对肿瘤浸润性淋巴细胞功能的作用 ;可溶性抗原封闭抗体;二、细胞毒细胞是免疫抑制性细胞因子的靶细胞;凋亡 ;表达FasL,并通过Fas-FasL相互作用而杀灭浸润的免疫效应细胞。;Detection of Fas ligand expression by immunofluorescence in a human lung carcinoma cell line. ;三、肿瘤细胞中抗原处理机制的缺陷;伴随蛋白;*;;; 缺乏协同刺激分子;第二节 肿瘤的免疫学治疗;Active Non-specific BCG, Propionibacterium acnes, levamisole, cytokine genes, etc. Specific killed tumor cells or their extract, recombinant antigens, idiotype, co-stimulatory molecule genes, etc. Passive Nonspecific LAK cells, cytokines Specific antibodies alone or coupled to drugs, pro-drug toxins or radioisotope; bispecific antibodies; T-cells Combined LAK cells and bispecific antibody * BCG: Bacillus Calmette Geurin is a bovine strain of Mycobacterium tuberculosis. ;Type of BRM examples bacterial product BCG, P. acnes, muramyl di -peptide, trehalose dimycolate synthetic molecules pyran, poly I:C, pyrimidines cytokines interferon-alpha, -beta, -gamma, IL-2, TNF ;;;;Figure1. Recurrent melanoma, unresponsive to radiotherapy, prior to immunotherapy with intralesional (病灶内的) injections of human monoclonal antibody to GM2 or GD2. GD3, a prominent ganglioside (神经节糖苷)on the surface of melanoma cells.;2、天然抗Gal抗体增强自体肿瘤免疫原性的作用;天然抗体;半乳糖成分: a-1,3-半乳糖苷 (Gala-1,3Gal);antibody;半乳糖成分: a-1,3-半乳糖苷 (Gala-1,3Gal);;;1、CML的细胞免疫治疗 2、骨髓移植后疾病复发的细胞免疫治疗;Treatment o leukemias by autologous (自体) bone marrow rescue. ;Treatment of leukemia w