《谢毅－白血病1》.pptVIP

xie Yi,Hua Shan Hospital Concept of leukemia Definition It is the results of the tumor proliferation of heamotopoietic stem cells.（造血干细胞） Leukemia is a malignant blood disorder. (not solid tumor) 　　　　　　　　 Heamatopoietic stem cell reproduction HSC lymphoid HSC HSC differentiation early progenitor CFU-GEMM myeloid HSC Heamatopoietic Stem Cell (HSC) is the primary cell of Heamatopoietic system and immune system. Tumor proliferation of HSC Differentiation of HSC is blocked. Leukemia cells are stopped on a differentiation stage of HSC lack of the normal function . Proliferation is out of control and apoptosis is inhibited. Leukemia cell is cloned and accumulated in a great quantity. infiltration and metastasis malignant blood disorders HSC differentiation is blocked. Normal blood cells are decreased and leukemia cell is increased. The function of Blood and immune system are short of. Fever ，bleeding ，anemia malignant blood disorders Proliferation is out of control ,apoptosis is inhibited and leukemia cell is accumulated in a great quantity. Leukostasis(白细胞淤滞) Abnormal morphology pictures of blood and bone marrow Liver,spleen,lymph nods, skin,CNS are infiltrated and dysfunctional frequently. According to the acute myeloid leukemia（AML） Differentiation M0 M1 M2 ……………….. M7 Kind of cell blast crisis of CML，mast cell leukemia， acute eosinophilic leukemia，basophilic………… leukemia acute lymphocyte leukemia（ALL） L1，L2，L3 T－ALL、B－ALL chronic leukemia： CML、P－LL、CLL、HCL、 …… WHO class