Counseling the HCV-Positive Donor咨询的HCV阳性供体.ppt

Example of Bias Matched Case-Control Study Lakkana Thaikruea MD., Cert of FETP, M.S., PhD. Department of Community Medicine, Faculty of Medicine, CMU Risk Factors for Hepatitis C Virus infection among Blood Donors in Northern Thailand Lakkana Thaikruea 1, Satawat Thongsawat 1, Niwat Maneekarn 1, David L. Thomas 2, Dale Netski 2, Kenrad E. Nelson 2, Rationale No effective program in Thailand to prevent HCV infection Lack of information of majors route of transmission Distribution of HCV genotypes are not well understood Researchers from JHU and Chiang Mai University have conducted study about epidemiology of HCV in northern Thailand Blood donor is one of the study population besides drug users, patients, and commercial sex workers This present study focuses on blood donor Specific aims Blood donors in northern Thailand 1. To investigate the potential risk factors for HCV infection 2. To determine HCV genotype distribution 3. To investigate relationship between HCV genotype distribution and the routes of transmission Features of hepatitis C virus infection Background: Route of transmission USA: IDU1, sex with an IDU, blood transfusion among non-IDU REDS2:** male, black, 30 to 49 years, high school diploma, first /only time blood donor, blood transfusion history Specific aim 1 Methods: Specific aim 1 Setting Design Data collection Data analysis Study setting Study design: Specific aim 1 Data collection Invitation letters: 2nd letter in 2 weeks apart Non-participants: sent their participation forms indicating their unwillingness Enrolment: explain, consent form Trained health personnel of the same gender: face-to-face interview Physical examination Counseling Laboratory tests: 30 ml blood HCV antibodies; EIA-3, RIBA-3 HCV RNA: RT-PCR HCV genotypes: direct sequencing Serum ALT Data collection (cont) PCR positive, or PCR negative with RIBA-3 positive, or PCR negative with b