冬4-心血管遗传与基因组医学-祁鸣.pptVIP

Na+ current (LQT3, Brugada syndrome). Transient outward K+ current Rapid component of delayed rectifier K+ current (LQT2 + LQT6) Slow component of the delayed rectifier K+ current (LQT1 + LQT5) Ultra-rapid component of the delayed rectifier K+ current L-type Ca2+ current Inwardly rectifying K+ current (Andersen syndrome) Myocardial Transmembrane Action Potential INa: Ito: IKur: IKr: INa (IKur) Ito IKr IKs ICa(L) IKir IKs: ICa(L): IKir: What Triggers the Symptoms? Exercise Emotional excitements Sleep Drugs 临床方法 病史：要点 三代家族系谱，特别询问晕厥，“癫痫发作”，猝死和先天性耳聋的情况。 辅助检查 心电图，测量QTc。 收集DNA样本进行分子遗传学分析。 鉴别诊断 Jev