编织型可降解输尿管支架管的制备工艺及其结构与性能-纺织工程专业论文 word格式.docxVIP

摘要形成一些孔洞；铜芯热处理支架管的压缩性能明显优于铁芯的，拉伸性能略低，铜芯热处理后支架管的表面较为平整光滑；经化学改性后支架管的拉伸和压缩性能都显著下降，支架管表面产生一些微孔或孔洞。对不同制备工艺制得的支架管进行了体外模拟降解试验，以探讨支架管拉伸性能、压缩性能、形貌以及质量损失率在降解过程中的变化规律，分析了齿轮比、编织纱线根数、化学改性处理等制备工艺参数对支架管性能在降解过程中变化的影响。结果表明，膜结构降解速度要快于纤维结构；齿轮比越小、编织纱线根数越少、化学处理时间越久，支架管降解越快。本课题的研究工作探讨和分析了编织过程中一些重要参数变化规律，为分析编织问题奠定了一定的基础；探讨了制备工艺与输尿管支架管性能之间的关系以及支架管性能在体外降解过程中的变化规律，为可梯度降解输尿管支架管的研制奠定了一定的基础。关键词：可降解输尿管支架管；编织工艺；化学改性；力学性能；降解性能IIPREPARATIONTECHNOLOGYOFBRAIDED BIODEGRADABLEURETERALSTENTAND ITS STRCTURES AND PROPERTIESABSTRACTUreteralstentsarewidelyusedinurologicpracticetokeepureteralpatency,assureurinaryflow,protectrenalfunction,andpreventureteralstrictureandobstruction.Atpresent,thestentsusedintheclinicalpracticearenondegradablewhichcausedmanycomplicationsandneedthesecondaryremovaloperation.Withtheenormousprogressofbiodegradablematerials,biodegradableureteralstentsarebeingextensivelystudied.Becauseoftheirdegradableproperties,theycouldrelieveoravoidsomecomplications,andalsoeliminatethesecondaryremovalsurgery.Onthebasisofpreviousworks,poly(glycolicacid)(PGA)andpoly(lactic-co-glycolicacid)(PLGA)multi-filamentswereselectedinthisstudy.PGAandPLGAmulti-filamentswerepliedintoayarn, andthensomeofthemwerebraidedontoaTeflon cordbyaconventional2-Dtubularbraidingmachine.Aftertheheattreatment,thebraidedureteralstenthadacompositestructureincludingthefiberandfilmcomponentswhichhadagoodtensilestrengthandcompressionresistance.Beforethebraidingprocessoftheureteralstents,theexperimentalworkandtheoreticalanalysisoftubularbraids’braidingprocesswasstudied.ThechangelawofbraidingangleandthreadtensionduringbraidingprocessandtheeffectofbraidingtechnologyonporesizeandsurfacecoveragewereinvestigatedThisstudyinvestigatedtherelationshipbetweentheprocessofbraidingandpost-processtreatmentandmechanicalpropertiesandmorphology.Theresultsshowedthatasthegearratiodecreased,thetensilestrengthofstentincreasedslightly,whileitscompressiveloaddecreasedsignificantlywithsomeporesonthestents.Asthenumberofbraidingyarnsdecreased,bothtensileandcom