Differential changes of metabolic brain activity and interregional functional coupling in prefronto-limbic pathways during different stress conditions functional imaging in freely behaving rodent （差变化的脑代谢活性和prefronto边缘通路不同应力条件下的功能成像在区域间的）.PDFVIP

ORIGINAL RESEARCH ARTICLE CELLULAR NEUROSCIENCE published: 10 May 2012 doi: 10.3389/fncel.2012.00019 Differential changes of metabolic brain activity and interregional functional coupling in prefronto-limbic pathways during different stress conditions: functional imaging in freely behaving rodent pups Jörg Bock 1,2 *, Anett Riedel 3 and Katharina Braun 1,3 1 Center for Behavioral Brain Sciences Magdeburg, Magdeburg, Germany 2 PG Structural Plasticity, Institute of Biology, Otto-von-Guericke University, Magdeburg, Germany 3 Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto-von-Guericke University, Magdeburg, Germany Edited by: The trumpet-tailed rat or degu (Octodon degus) is an established model to investigate Nicola Maggio, The Chaim Sheba the consequences of early stress on the development of emotional brain circuits and Medical Center, Israel behavior. The aim of this study was to identify brain circuits, that respond to different Reviewed by: stress conditions and to test if acute stress alters functional coupling of brain activity Mathias V. Schmidt, Max Planck Institute of Psychiatry, Germany among prefrontal and limbic regions. Using functional imaging (2-Fluoro-deoxyglucose Aron Weller, Bar-Ilan University, method) in 8-day-old male degu pups the following stress conditions were compared: Israel (A) pups together with parents and siblings (control), (B) separation of the litter from the