口腔粘膜精品教学（中山大学）2.溃疡类.pptxVIP

Oral Mucosal Disease ;Contents;Diseases at a glance;After this class, you should: Clearly understand the characteristics, clinical classification therapeutic principles of recurrent aphthous ulcer ;Ulcerative Lesions of Oral Mucosa ;Recurrent aphthous ulcer(RAU);Recurrent aphthous ulcer;Recurrent aphthous ulcer;Recurrent aphthous ulcer;RAU(Herpetiform);Recurrent aphthous ulcer;;Recurrent aphthous ulcer;Recurrent aphthous ulcer;Recurrent aphthous ulcer;Recurrent aphthous ulcer;* 具有非特异免疫抑制作用的药物 ——反应停(Thalidomide) 25-50mg p.o. qn 1- 2 month 能迅速减轻症状、明显缩短发作期 美国FDA已批准用于治疗AIDS的口腔溃疡损害 需注意其致畸作用，孕妇禁用，育龄妇女慎用;Recurrent aphthous ulcer;Recurrent aphthous ulcer;Recurrent aphthous ulcer;治疗方案设计方案1：一般的局部用药，合用营养因子、  中成药或中医辨证施治 (基础用药,低发)方案2：皮质激素损害下局部注射 (重型)方案3：中小剂量皮质激素的全身应用 (各型,频发) 方案4：免疫调节剂的全身应用 (各型,频发) 方案5：反应停等非特异免疫抑制药物的全 身应用 (各型,频发) 方案6：免疫抑制剂的全身应用 (各型,频发) ;治疗方案选择 根据：RAU病损的发作频率高：间歇期1周，中：间歇期1~4周，低：间歇期4周发作频率 临床分型 治疗方案高、中、低 各型 方案1（基础用药）高 各型 首选方案3或方案5，必要时合 用方案6，如无效改用方案4中 轻型 首选方案4 重型 方案2和方案4低 轻型 选择方案1 重型 选择方案2；无效改用方案4高、中、低 疱疹样型 方案3或方案5;;Beh?et’s Disease;Beh?et’s Disease;Beh?et’s Disease;at least 95% BDpatients Mainly by minor type The first systemic manifestation (about 70% cases) ;Genital lesions: RAU;Characteristic skin lesions: Left: Erythema nodosum-like lesions (结节性红斑) Right: folliculitis (毛囊炎);skin pricked reaction;Beh?et’s Disease;Beh?et’s Disease;Beh?et’s Disease;Meditation;Traumatic mucosal hematoma traumatic ulceration;Traumatic hematoma ulcer;Traumatic hematoma ulcer;Traumatic hematoma ulcer;Traumatic hematoma ulcer;Traumatic hematoma ulcer;Traumatic hematoma ulcer;;Oral mucositis;1. Signs and symptoms Time