羟丁基壳聚糖温敏水凝胶及其血管栓塞载体的研究-遗传学专业论文 word格式.docxVIP

优秀毕业论文 精品参考文献资料 The re与serch of hydroxybutyl chitos与n sensitive hydrogel 与s 与 blood vessel embolism c与rrier Abstr与ct Recently, much attention has been paid on injectable hydrogels in the ?elds of biomaterials and polymer science. These materials are ?owable aqueous solutions before administration, but gel rapidly under the physiological condition. Hydrogels that are hydrophilic three-dimensional polymeric networks capable of absorbing large quantities of water have been widely used in biomedical ?eld as wound dressing, drug delivery systems and tissue engineering scaffolds. Chitosan, generally derived from naturally abundant chitin, is a non-toxic, biocompatible, and biodegradable material. However, due to the existence of strong intramolecular and intermolecular hydrogen bonding interactions of chitosan and stable crystallization, chitosan have poor dissolving property. Chitosan can only be dissolved in a dilute acid solution, e.g. dilute sulfuric acid, dilute hydrochloric acid and acetic acid, etc., which greatly limits its application. Thus enhancement of the dissolving properties of chitosan, especially the water solubility, is an important research direction in the study of modified chitosan. In this paper, we used 1, 2 - butylene oxide as the etherifying agent and introduced hydroxybutyl to the chitosan under alkaline conditions to obtain water-soluble hydroxybutyl chitosan (HBC). Furthermore, reagent dosage, reaction temperature, reaction time were researched and the best preparation conditions of hydroxybutyl chitosan were preliminary determined. In this paper, we prepared different concentrations of HBC solutions, and concentrated HBC aqueous solution could transform into hydrogel within 30 s after injection under physiological temperature in non-chemical fashion. The properties of the HBC gels including chemical structure, surface morphology and rheological properties were studied. Gelation temperature and gelation time of HBC could be adjuste