nasids相关胃肠道损伤的ppi应用 课件.pptVIP

tttttttttttttttttttttttttttttttttttttttttttttt 贝尔女士，让我们再次看一次这些药物。第一瓶是用于治疗关节炎的药品。第二瓶可以保护你的胃免受第一瓶药物的损害。第三瓶可以保护你的心脏免受关节炎药物的损害。最后一瓶则用于缓解你对前三瓶药物的焦虑。 总结 阿司匹林及NSAIDs胃肠道损伤值得重视 应根据消化系统及心血管系统风险选择用药策略 PPI具有较好的防治作用 谢谢！ * * * * * * 据统计，服用非选择性NSAIDs 2个月以上会导致以下严重后果 ： 5名患者中有1人发生内镜下溃疡 ； 68名患者中有1人发生症状性溃疡 ； 145名患者中有1人发生出血性溃疡； 1200名患者中有1人死于出血性溃疡。 可见，非选择性NSAIDs的胃肠道的损害是多么严重，百年难题，并非危言耸听！ * * NSAIDs are among the most widely prescribed medications for the treatment of pain and inflammation; patients with chronic disease such as arthritis often take these drugs for more than 30 years, and therefore, over the course of a lifetime, the risk of GI complications or death is substantial.1 The implications of NSAID-associated GI complications, for both the patient and the healthcare provider, are great: In the United States, of the 13 million people with arthritis taking NSAIDs, it is estimated that 103,000 patients per year are hospitalized for NSAID-associated serious GI complications.1 At a conservative estimated cost of $15,000 to $20,000 per hospitalization, this amounts to an annual cost for the United States that exceeds $2 billion.1 In the United States, it is estimated that 16,500 patients per year will die of NSAID-associated serious GI complications.1 This mortality rate makes NSAID-associated GI complications the 15th most common cause of death in the United States.1 These data include the following NSAIDs: aspirin, flurbiprofen, sulindac, piroxicam, ibuprofen, indomethacin, meclofenamate, fenoprofen calcium, naproxen, ketoprofen, salsalate, tolmetin sodium, nonacetylated salicylates, and diclofenac sodium. The data do not include other (nonarthritis) indications, or over-the-counter NSAIDs.1,2 Singh, Triadafilopoulos. J Rheumatol. 1999;26:18-24. Singh, et al. Arch Intern Med. 1996;156:1530-1536. * * The GI adverse events associated with NSAID use can be life-threatening, and are associated with high mortality. Patients with upper GI bleeding are at a high risk of death: Worldwi