重症感染性休克患者治疗前后血清血管粘附蛋白.docVIP

感染性休克患者治疗前后血清血管粘附蛋白-1及血浆多配体 蛋白聚糖-1水平变化 宋根红 延安大学附属医院重症医学科 陕西 延安 邮编716000 【摘要 目的： 方法：2013年9月-201年月院重症监护病房P＜0.05P＜0.05P＜0.05 【关键词：Serum Vascular Adhesion Protein-1 and Plasma Syndecan-1 Levels Before and After Treatment in Patients with Septic Shock Song Genhong Department of Intensive Care Unit, Hospital of Yanan University，ShanXi Yanan，716000 Abstract Objective：The purpose of this study was to investigate the serum vascular adhesion protein-1 (VAP-1) and syndecan-1 (SDC-1) levels before and after treatment in patients with severe septic shock. Methods：The clinical data of 50 patients with septic shock in the ICU in the hospital from September 2013 to June 2014 were collected for this study as observation group, 50 healthy adults in our hospital physical examination center as control group. The serum levels of VAP-1 and plasma SDC-1 were compared before and after treatment on days 1, 3 and 5. At the same time, the differences of serum VAP-1, plasma SDC-1 levels and APACHE II scores on admission were compared between survivors and non-survivors in observation group. Results: The serum level of VAP-1 and plasma SDC-1 levels were significantly higher in septic shock group than control group before treatment and after treatment on days 1, 3 and 5 (P＜0.05serum level of VAP-1 and plasma SDC-1 levels were increased gradually after treatment in the 1st day and the 3rd day, and significantly lower on day 5 compared day 3 (P＜0.05serum level of VAP-1, plasma SDC-1 levels and APACHEⅡ scores in 35 survived patients were significantly lower than 15 died patients(P＜0.05Conclusion：Early combined detection of VAP-1 and SDC-1 in patients with severe septic shock could help to evaluate the severity of disease and prognosis. Keywords: Severe septic shock；Vascular adhesion protein-1；syndecan-1 感染性休克是一种临床常见的综合征 1 资料与方法 1.1 资料来源 选择201年9月-2014年月院重症监护病房收治的，男性例，女性例，年龄-72岁，平均年龄±9.8岁；中，男性例，女性例，年龄35-7岁，平均年龄±10.5岁组在年龄及男女比例上无显著差异，具有可比性。 1.2 纳入与排除标准 纳入的例患者均符合中华医学会制定的感染性休克的临床诊断标准，即所有患者出现以下症状或检查结果：