平消胶囊用于肿瘤协同治疗的临床证据.PDFVIP

Practice and Communication Chin J Evid-based Med 2013, 13(8): 1018-1024 平消胶囊用于肿瘤协同治疗的临床证据 1 2 3* 花宝金  杜  亮  唐荣欣 1. 中国中医科学院广安门医院（北京 100053）；2. 四川大学华西医院中国循证医学中心（成都 610041 ）； 3. 上海市长宁区妇幼保健院（上海 200051 ） 摘要  目的  系统检索平消胶囊用于肿瘤协同治疗的临床证据，以期为临床应用提供参考。方法 计算机检 索CBM、CNKI、VIP 、WanFang Data 和MEDLINE 数据库，检索时限均为从建库至2013 年2 月，查找平消胶囊用 于肿瘤协同治疗的随机和非随机临床对照研究，而后分病种进行证据综述。结果 共检出文献 1 097 篇，最终纳入 随机对照研究41 篇，非随机对照研究 15 篇。现有证据显示：平消胶囊已用于多种肿瘤的协同治疗，可提高放化疗 疗效，降低放化疗毒副反应，且能提高患者生存质量。结论 当前证据显示，在放化疗的基础上，应用平消胶囊辅 助治疗肿瘤，其疗效和安全性优于单纯放化疗。但由于纳入研究质量有限，上述结果仍需进一步高质量研究验证。 关键词 平消胶囊；肿瘤辅助治疗；临床证据 Clinical Evidence of Pingxiao Capsule for Tumor Adjuvant Treatment 1 2 3* HUA Bao-jin , DU Liang , TANG Rong-xin 1. Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; 3. Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China; 2. Shanghai Changning Maternity Infant Health Hospital, Shanghai 200051, China Abstract Objective To review the clinical evidence of Pingxiao Capsule for tumor adjuvant treatment so as to provide some decision-making references for clinical practice. Methods We electronically searched CBM, CNKI, VIP, WanFang Data and MEDLINE (from inception to Feb, 2013) to collect the randomized controlled trials (RCTs) and non- randomized controlled trials (non-RCTs) about Pingxiao Capsule for tumor adjuvant treatment. Then, the included stud- ies were summarized and evaluated according to the classification of diseases. Results 1 097 potential relevant articles were searched. We included 41 RCTs and 15 non-RCTs. The results showed that Pingxiao Capsule used as an adjuvant therapy in treating tumor improved the efficacy and reduced the side effects of radiation and chemotherapy, and also improved the quality of survival. Conclusion Current evidence s