新型有机小分子凝胶剂的合成、组装及性能研究-物理化学专业论文.docx

关键词：有机小分子凝胶水凝胶自组装自修复药物包裹与释放IV万方数据AbstractIn recent years，as novel self-assembled materials，low-molecular-mass organic gelators (LMOGs)have received considerable attention．They can assemble into networks by means of various noncovalent interactions，such as hydrogen bonds，coordination interactions， hydrophobic interactions，冗-7c interactions and van der Waals forces，etc．Then the networks with solutions form gels．As the gels have the properties of thermally reversible，self-healing， relatively low cytotoxicity and rapid response to external environmental stimulation．And SOthey have developed into functional materials which have numerous potential applications．Inthis thesis，we designed and synthesized novel LMOGs．We characterized the compounds and studied the properties of gels and the process of self-assembly through advanced technologies． Besides，we also explored the potential applications of the gels．The whole paper mainlycontains the following two parts：1、Vesicle-tube-fibre evolution via spontaneous fusion and its applicationswe introduced 4-aminoantipyrine，which has been extensively applied in dyes， biomedicine，pesticides and environmental fields，into the ALS system for the first time．Here， 4-amino．2，3．dimethyl—pyrazolone was used as the linker to construct a new kind of gelator．A real．time reversible fusion pathway from vesicles to fibres，passing through several types of intermediates such as fused vesicles and short and long tubes，was monitored in the assembly．The mechanism of the structural evolution via a gelation process was studied bymeans of electronic microscopy，small-angle X—ray scattering and powder X-ray diffraction． The fibres of the gel tissue could be switched by sonication and mechanical shaking to tubesand broken fibres，respectively，the destroyed fibres could match with each other in the healing process，showing the self-healing and self-correcting character of the self-assembly． We also studied the reversed process by thermal treatment．This complet