同步辐射光源微血管成像研究-生物化学与分子生物学专业论文.docx

radiation and contrast agents played an important role in the synchrotron radiation imaging.Preliminary study on the morphology of tumor angiogenesis was also executed by establishing 4T1 tumor animal models with or without contrast agents. The imaging results showed that the tumor vessels with the diameter of less than 30 micron were able to be observed by synchrotron radiation without contrast agents in windows model.The above results showed the feasibility of observation of microvessels in mouse brain and tumor. Further study on the pathogenesis, diagnosis and treatment of brain diseases and tumor by establishing animal models will be investigated.KEYWORDS:synchrotronradiation,phasecontrastimaging, microvessel, contrast agent目 录摘 要 ............................................................................................................................IIABSTRACT............................................................................................................... III第一章 前言 .................................................................................................................11．1 微血管研究的重要性及其现状 .......................................................................11. 1. 1 脑部微血管的研究意义及现状.................................................................11. 1. 2 肿瘤微血管的研究意义及现状.................................................................31．2 同步辐射 X 射线的医学应用51. 2. 1 同步辐射光源的发展概况..........................................................................51. 2. 2 同步辐射 X 射线相衬成像71. 2. 3 同步辐射 X 射线成像在血管成像方面的应用81．3 利用同步辐射 X 射线研究微血管的重要意义 161．4 本文的主要内容 .............................................................................................17参考文献 .....................................................................................................................18第二章 同步辐射光源对小鼠脑及其他正常血管的形态学研究 ...........................222．1 引言 .................................................................................................................222．2 实验方法和材料 ..