腰痛静息态功能磁共振比率低频振幅的研究-中国康复医学杂志.PDF

ChineseJournalofRehabilitationMedicine, Feb.2017,Vol. 32, No.2 ·临床研究· 腰痛静息态功能磁共振比率低频振幅的研究* 1,2 2 1,4 3 张珊珊 吴 文 王楚怀 杨建明 摘要 目的：采用功能磁共振成像（fMRI）技术和比率低频振幅（fALFF）方法探讨静息状态下腰痛脑功能变化的特点。 方法：采用3.0T 磁共振成像仪采集12例健康志愿者（7 男5 女，23.8±3.6 岁）正常状态与腰痛状态（肌肉注射5%高渗 盐水）的静息态fMRI 数据。采用DPARSF 软件对所得数据进行预处理和fALFF 分析、SPM8 进行配对t 检验比较两 种状态下脑比率低频振幅的差异，并将疼痛状态的图像与疼痛强度VAS 评分作相关性分析。 结果：与正常状态相比，腰痛fALFF 值增高的脑区包括双侧额下回、双侧小脑扁桃体、右海马旁回，fALFF 值降低的 脑区包括右额上回、右后扣带回、左初级躯体感觉皮质（S1）、双侧枕叶（P ＜0.001 ，体素K≥10）。腰痛状态右额下回 fALFF 值与VAS 评分呈正相关，左S1、左枕叶fALFF 值与VAS 评分呈负相关（P ＜0.005 ，K≥10）。 结论：静息状态下腰痛受试者部分脑区存在脑功能活动异常，这可能与疼痛刺激引起认知、情绪功能改变有关。 关键词 腰痛；静息态；功能磁共振成像；比率低频振幅 中图分类号：R681.5, R445.2 文献标识码：A 文章编号：1001-1242（2017 ）-02-0140-06 Altered fractional amplitude of low frequency fluctuation in experimental low back pain: a resting-state fMRI/ZHANG Shanshan, WU Wen, WANG Chuhuai, et al.//Chinese Journal of Rehabilitation Medicine, 2017, 32(2): 140—145 Abstract Objective: To explore the characteristics of the fractional amplitude of low frequency fluctuation (fALFF) in ex- perimental low back pain using resting-state functional magnetic resonance imaging (fMRI). Method: Twelve healthy subjects (male: 7, female: 5; age: 23.8±3.6 years ) were separately performed resting- state fMRI 3.0T scans at no-pain (baseline) and pain of the back muscle (intramuscular injection of 5% hyper- tonic saline) situation. The fMRI datas were analyzed with paired t- test to compare fALFF changes of the brain between baseline and pain status by DPARSF, and SPM8. Correlation analysis was performed between the fALFF images during low back pain and pain intensity (visual analogue scale, VAS). Result: Subjects with low back pain showed significantly increased fALFF in bilateral inferior frontal gyrus, bi- lateral cerebellum