hdl与ldl风险评估与治疗ppt课件.pptVIP

HDL-C in Clinical Practice Risk assessment Routinely measured in all adult patients HDL-C 35 mg/dL is a major positive risk factor HDL-C ?60 mg/dL is a negative risk factor; subtract 1 risk factor from total Risk reduction Nonpharmacologic therapy (exercise, weight loss, smoking cessation) Pharmacologic therapy Clinical trial data show decreased CAD progression and decreased CAD events with increased HDL-C Progression (MLD decrease), mm HDL-C 35 mg/dl (p=0.0004) n=43 n=25 HDL-C ?35 mg/dl (p=0.09) n=128 n=143 0.065 0.274 0.036 0.083 p=0.01 Ballantyne CM et al. Circulation 1999;99:736-743. Redu