急性心衰与心源性休克ppt课件.pptVIP

Positive Inotropes Increase cAMP Beta agonists through receptor activation of adenyl cyclase Phosphodiesterase inhibitors- reduce cAMP breakdown Net effect: increased rate and extent of calcium influx during systole resulting increased contractility increased reuptake of calcium by endoplasmic reticulum during diastole improves active relaxation (lusitropic) Adrenergic agonists: dopamine (Intropin), dobutamine (Dobutrex), norepinephrine (Levophed), epinephrine Phosphodiesterase inhibitors: amrinone (Inocor), milrinone (Primacor) Digoxin? Why not? * Dopamine (Intropin) Intrinsic neurotransmitt