全身热疗对放射性肺炎预防作用的临床研究-肿瘤学专业论文.docx

Effect of Whole body hyperthermia on preventing radiation pneumonia.Specialized field: OncologyPostgraduate student: Huang ZhongSupervisor:Shao Xun fan chief physicianAbstractBackground：In China, Lung cancer has the highest incidence and mortality among malignant tumors and is still increasing rapidly. However, only 20%-30% of the patients after early detections can accept the surgical resection and approximately 80% of the patients lose the opportunity to have curative resection, therefore, the comprehensive treatment method which is based on radiotherapy and chemotherapy becomes the significant treatment for ad125vanced cancer.Radiotherapy can make lung tissue which close to tumor cause radiation-induced lung injury of varying degrees for the reason that the radiation dose exceeds threshold of biological effects, furthermore, it leads to death through heart and pulmonary circulation failure.Radiation-induced lung injury is the most common complication for the patients of common chest malignancies after receiving chest radiation therapy. And it becomes one of the most limiting factors of the radiation dose of the patients who accept the chest radiation therapy as it directly affects the efficacy of the patients.In recent years, it is gradually reported that whole body hyperthermia combined with radiotherapy and chemotherapy can improve the efficacy of advanced lung cancer. Whole body hyperthermia increase tumor cell killing, meanwhile it will not lead to more complication caused by radiotherapy, to some extent, it will reduce complication caused by radiotherapy.Research purpose:Analyze clinical effects of whole body hyperthermia in the prevention of radiation pneumonitisAnalyze the potential mechanism.Material and method:Select the initial treatment of 97 patients with stage Ⅲ-IV unresectable NSCLC, into radiotherapy and chemistry treatment combined with whole body hyperthermia group（HT+RT+CT） and radiotherapy and pharmaceutical chemistry treatment group（RT+CT）. Th