dtmp活性肽的筛选及其对放射损伤小鼠血小板减少症的救治作用分析word格式论文.docx

文献综述促分裂原活化蛋白激酶家族(MAPKs)对巨核细胞增殖分化及血小板生成调控的研究进展 65参考文献 72攻读学位期间的研究成果 75致谢 76缩略语表英文缩写AA英文全称Aplastic Anemia中文全称再生障碍性贫血BFUBurst-forming unit爆炸式集落形成单元BSABovine serum albumin牛血清清蛋白CCK-8Cell Counting Kit-8细胞计数检测试剂盒-8CFUColony-forming unit集落形成单元DMSODimethyl Sulfoxide二甲亚砜EMPErythropoietin mimetic peptide促红细胞生成素模拟肽EPOErythropoietin促红细胞生成素EPORErythropoietin receptor促红细胞生成素受体FBSFetal bovine serum牛胎儿血清FITCFluorescein isothiocyanate异硫氰酸荧光素GHGrowth hormone生长激素GM-CSFGranulocyte-macrophagecolonystimulating factor粒细胞与巨噬细胞集落生 长刺激因子GlyGlycine甘氨酸HPPCHigh Proliferative-potential cell高增殖活性细胞HPCHigh-performance computer高性能计算机HSAHuman serum albumin人血清白蛋白IL-3Interleukin-3白介素-3ITPIdiopathic thrombocytopenic purpura特发型血小板减少性紫癜KDKilodaltons千道尔顿1LysLysine赖氨酸M-PERMammalian Protein extraction reagent哺乳类动物蛋白提取试剂MPIMessage Passing Interface并行计算环境ODOptical density光学密度值PBSPhosphate balanced solution磷酸盐缓冲溶液PEG-rhMGDFPegylated recombinant human megakaryocyte growth and development factor经聚乙二醇化的重组人巨 核细胞发育生长因子ProProline脯氨酸rhTPORecombinant human thrombopoietin重组人促血小板生成素SCFStem cell factor干细胞因子SDSSodium dodecyl sulfate十二烷基硫酸钠 十二烷基硫酸钠-聚丙烯酰SDSSDS-polyacrylamide gel electrophoresis胺凝胶电泳SerSerine丝氨酸TMPThrombopoietin mimetic peptide促血小板生成素模拟肽TPOThrombopoietin促血小板生成素TPORThrombopoietin receptor促血小板生成素受体2Screening for a tandem dimer of TMP with potent thrombopoietic activity and its effect on treating radiation-induced thrombocytopenia in miceAbstractWith the extensive use of nuclear technology, the negative effects generated from nuclear weapon, reactor accidents and nuclear terrorism are inevitable under certain conditions.Thrombocytopenia is often resulted from radiation exposure and radioactive contamination, and it is also a major hematopoietic disease caused by various reasons such as Aplastic Anemia (AA), idiopathic thrombocytopenic purpura (ITP) and the side effects of chemotheropy/radiotherapy for tumor treatment. How to effectively promote thrombopoiesis is desirable for the treatment of thrombocytope