fhit wwox在涎腺恶性肿瘤中表达和意义word格式论文.docxVIP

优秀毕业论文 精品参考文献资料 frequent than that in low/intermediate MEC.Statistically this difference does reach a signifi cant level (P=0.03 and P=0.035, respectively). Reduced Fhit and Wwox expression in tubular/cribriform type of ACC was achieved more frequent than that in solid type of ACC. statistically signifi cant results were observed(P=0.017,P=0.014,respectively). A signifi cantly positive relationship was achieved between Fhit and Wwox in salivary gland neoplasms(MEC and ACC)(r=0.433,P=0.009;r=0.427,P=0.038).There was no relationship between the expression of Fhit and Wwox proteins and age、sex 、tumor size and tumor site(P0.05). Fhit and Wwox protein expression was decreased or lost signifi cantly more common in ACC,a basaloid tumor(P=0.016 and P=0.039, respectively). [Conclusion]In accordance with previous studies, concordant lost or reduced Fhit and Wwox expression might play a important role in the initiation of salivary gland malignant neoplasms, with loss signifi cantly more frequent in basal-like cancers ,similarly to breast cancer. Inactivation in common fragile tumor suppressor genes ,FHIT and WWOX ,which are more susceptible to environmental carcinogens, occur quite early in the development of many types of human cancers. Therefore, common fragile gene therapy could be a novel clinical target for the treatment and prevention of early-stage malignancies ,especially in basal-like cancers. [Key words]Mucoepidermoid carcinoma(MEC); adenoid cystic carcinoma(ACC);Fhit; Wwox; Basal-like phenotype; Immunohistochemistry  独创性声明 本人声明所呈交的学位论文是我个人在导师指导下进行的研究工作及取得的研 究成果。尽我所知，除文中已经标明引用的内容外，本论文不包含任何其他个人或集 体已经发表或撰写过的研究成果。对本文的研究做出贡献的个人和集体，均已在文中 以明确方式标明。本人完全意识到，本声明的法律结果由本人承担。 学位论文作者签名： 日期： 年 月 日 学位论文版权使用授权书 本学位论文作者完全了解学校有关保留、使用学位论文的规定，即：学校有权保 留并向国家有关部门或机构送交论文的复印件和电子版，允许论文被查阅和借阅。本 人授权华中科技大学可以将本学位论文的全部或部分内容编入有关数据库进行检索， 可以采用影印、缩印或扫描等复制手段保存和汇编本学位论文。  本论文属于 保密□ ，在 年解密后适用本授权书。 不保密□。  （请在以上方框内打“√”） 学位论文作者签名： 指导教师签名： 日期： 年 月 日 日期： 年 月 日 华 中 科 技 大 学 硕 士 学 位 论 文  PAGE 38