fhit wwox在涎腺恶性肿瘤中的表达和意义word格式论文.docxVIP

优秀毕业论文 精品参考文献资料 [结论]与以前的研究结果一致，Fhit 和 Wwox 表达的减少或缺失在涎腺恶性肿瘤的 发生过程中发挥了重要作用，尤其与基底细胞样型癌（ACC）密切相关。常见染色体 脆性位点抑癌基因对环境中的致癌因素相当敏感，它们的失活和异常表达常发生在癌 性肿瘤的早期。因此，常见脆性位点基因可以作为恶性肿瘤预防和早期治疗的全新靶 点，特别是基底细胞样型癌。 [关键词]粘液表皮样癌（MEC）；腺样囊性癌（ACC）； Fhit ；Wwox；基底细胞样型； 免疫组织化学  Expression of Fhit and Wwox in salivary gland malignancies and their significance Candidate: Yang Qingqiang Supervisor: Prof.Zhu Shengrong Abstract [Objective]Mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC) which have divergent morphological features and clinical behavior are the most common salivary gland malignancies. FHIT and WWOX are tumor suppressor genes that have been found to span the FRA3B and FRA16D which are the most sensitive common chromosomal fragile site loci at chromosomes 3p14.2 and 16q23.3, respectively in the human genome. Recent studies indicate concordant loss of Fhit and Wwox expression in the process of breast cancer, with signifi cantly more frequent loss in cancers of basal-like phenotype. In our study,we want to detect the expression and significance of Fhit and Wwox in salivary gland neoplasms(MEC and ACC)and analyze if there is a similar correlations in cancers of basal-like phenotype. [Methods]the expression of Fhit and Wwox proteins was investigated by immunohistochemistry SP method in 59 cases of salivary gland neoplasms, 35 MEC and 24 ACC，and 15 cases of normal salivary gland tissues. We divided MEC into two groups, high-grade and low/intermediate.; while ACC was divided into tubular/cribriform type and solid type. SPSS 17.0 Software was used to evaluate the correlation between the expression of Fhit and Wwox proteins and clinicopathological characteristics and the disparity in salivary gland neoplasms(MEC and ACC). [Results]We found reduced Fhit and Wwox proteins expression in salivary gland neoplasms(MEC and ACC) was significantly higher than that in normal salivary gland tissues (P＜0.05).Reduced Fhit and Wwox expression in high-grade MEC was found more  frequent than