鲑鱼降钙素对绝经后骨质疏松症的预防与治疗效果的meta研究word格式论文.docxVIP

鲑鱼降钙素对绝经后骨质疏松症的预防与治疗效果的 meta 分析中文摘要鲑鱼降钙素对绝经后骨质疏松症的预防与治疗效果的meta 分析 中文摘要【摘要】目的：综合评价绝经后妇女使用鲑鱼降钙素的治疗效果。方法：对 Pubmed ,Embase,Ovid, SpringerLink,Web of science 数据库中关于鲑鱼降钙素治疗绝经 后骨质疏松症的随机对照文献进行归纳，选取治疗前后腰椎骨密度变化率、疼痛改变 和新发骨折率作为参考指标建立数据库，将其结果汇总分析。按照 Cochrane 系统评 价方法对纳入研究的文献质量进行评价，采用 Revman 5.0 软件进行统计分析，评估 鲑鱼降钙素对绝经后骨质疏松症的功效。结果：最终纳入 7 篇随机对照试验，样本量共计 450 例。其中治疗组 224 例，对照组 226 例。Meta 汇总分析显示鲑鱼降钙素对 对绝经后骨质疏松症骨密度的进一步丢失具有预防效应，对绝经后骨质疏松症引起的 疼痛具有明显缓解作用，对绝经后骨质疏松症新发骨折率的降低有预防作用，但不具 有统计学意义。结论：鲑鱼降钙素在治疗与预防绝经后骨质疏松症方面具有明显的作 用。【关键词】鲑鱼降钙素；绝经后骨质疏松症；骨密度；Meta 分析；作者：黄昌佳 指导教师：蔡明英文摘要鲑鱼降钙素对绝经后骨质疏松症的预防与治疗效果的 meta 分析Meta Analysis on the prevention and treatment effect of salmom calcitonin in post-menopausal osteoporosis.AbstractObjective: The purpose of this study was to evaluate the effect of salmom calcitonin in post-menopausal osteoporosis. Methods: Computer retrieved was conducted to search for relevant RCTs(randomized controlled trails) about the treatment of salmom calcitonin in post-menopausal osteoporosisin Pubmed,Embase,Ovid, SpringerLink and Web of science. The quality of included studies was critically evaluated and data were analyzed by using the Cochrane Collaboration’s Revman 5.0 software. Results: A total of six RCTs including 450 patients of which 224 patients in treatment group and 226 patients in control group were involved in this meta-analysis.Meta-analysis shows statistically significant difference between the two groups.Conclusion: The result showed that salmom calcitonin had the greatest effect on BMD in post-menopausal osteoporosis[Key words] Salmom Calcitonin; Postmenopausal Osteoporosis; Bone mineral density; Meta AnalysisWrittenby Huang ChangjiaSupervised by Cai Ming目录序言1研究对象3方法4结果5讨论9结论13参考文献14综述17中英文缩略词表39攻读学位期间公开发表的论文40致谢41鲑鱼降钙素对绝经后骨质疏松症的预防与治疗效果的 meta 分析序 言序言根据世界卫生组织（WHO）的定义[1]，骨质疏松（osteoporosis，OP）是一种骨 骼系统疾病，患者骨量减少、骨的微结构破坏，骨的脆性增加，骨折危险性增加。2001 年美国国立卫生研究院（NIH）把骨质疏松症定义为“以骨强度下降而易于骨折为特 征的骨骼系统疾病”。骨质疏松诊断标准是根据白人绝经后妇女人群数据而制定的： 根据双能 X 线骨密度仪（DXA）测量的骨密度（BMD），如果测量 DXA BMD 值低 于正常青年妇女平均值-2.5 个