加减三甲散及其虫类药对肝纤维化大鼠tgf-βsmads信号通路及mmpstimps体系影响的研究-effects of modified sanjiasan and its insect drugs on tgf - β smads signaling pathway and mmpstimps system in rats with liver fibrosis.docx

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加减三甲散及其虫类药对肝纤维化大鼠tgf-βsmads信号通路及mmpstimps体系影响的研究-effects of modified sanjiasan and its insect drugs on tgf - β smads signaling pathway and mmpstimps system in rats with liver fibrosis.docx

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加减三甲散及其虫类药对肝纤维化大鼠tgf-βsmads信号通路及mmpstimps体系影响的研究-effects of modified sanjiasan and its insect drugs on tgf - β smads signaling pathway and mmpstimps system in rats with liver fibrosis

加减三甲散及其虫类药对肝纤维化大鼠加减三甲散及其虫类药对肝纤维化大鼠 TGF-β/Smads 信号通路及 MMPs/TIMPs 体系影响的研究成都中医药大学博士学位论文成都中医药大学博士学位论文44 PAGE PAGE 11Conclusions:JJSJS reduces the fibrotic degree of rats hepatic tissue significantly which means that this formular has powerful anti-fibrosis effect.JJSJS inhibits expression of TGF-β1 and Smad2/3 in hepatic tissues and increases the expression of Smad7.It is better than the colchicines.It has powerful anti-fibrotic effect through inhibiting the TGF-β/Smad pathway.There isn’t different between the JJSJS and the colchicines in decressing the expression of TNF-α in hepatic tissue in the fibrosis rats.JJSJS decresses the expression of TIMP-1mRNA,TIMP-2mRNA and MMP-2mRNA in hepatic tissue in the fibrosis rats, so it suppresses ECM’s degradation process by decresses the expression of MMP-2mRNA.It has not difference between the JJSJS and the insect drugs group in decressing the expression of TIMP-1mRNA.Keywords: jiajiansanjiasan(JJSJS); hepatic fibrosis, TGF-β/Smad pathway, MMPs/TIMPs system英文缩略词对照表缩略词英文全称中文全称ACE-I Blood vessel tense element transformation enzyme inhibitor血管紧张素转换酶抑制剂ALB albumin 白蛋白ALP Alkaline phosphatase 碱性磷酸酶ALT alanine amiotransferase 丙氨酸氨基转移酶AP-1 activator protein 1 活化蛋白质 1α-SMA alpha-sooth muscle actin a-平滑肌肌动蛋白BSA bovine serum albumin 牛血清白蛋白CCL4 carbon tetrachloride 四氯化碳Cl chlorine 氯CDK Cyclin dependent kinase 细胞周期蛋白依赖性激酶DAB diaminobenzidine 二氨基联苯胺DEPC Diethyl pyrocarbonate 焦碳酸二乙酯ECM Extra-cellular matrix 细胞外基质ET Endothelin 内皮素FN Fibronectin 纤维连接蛋白GGT Gamma-glutamyl tranzpehtidaze γ 谷氨酰转肽酶GPT Glutamic-pyruvic transaminase 谷丙转氨酶HA hyaluronic acid 透明质酸HBsAg hepatitis B surface antigen 乙型肝炎表面抗原HBV hepatitis B virus 乙型肝炎HC Hepatocyte 肝细胞HCV hepatitis C virus 丙型肝炎HE Hematoxyclin and eoxsin 苏木精和伊红（染色）HEV hepatitis E virus 戊型肝炎HRP horse radish peroxidase 辣根过氧化物酶1010 PAGE PAGE 11HSC Hepaticstellatecells 肝星状细胞HYP hydroxyproline 羟脯氨酸IB indirect Bilirubin 间接胆红素IFN-α Interferon-α α-干扰素IFN-γ Interferon-γ γ-干扰素IL Interleukin 白细胞介素IV-C Type