健脾除湿 疏利少阳法治疗慢性肾小球肾炎的临床分析-clinical analysis of jianpi chushi shuli shaoyang method in treating chronic glomerulonephritis.docxVIP

中文摘要试验目的：初步评价健脾除湿、疏利少阳法治疗慢性肾小球肾炎的有效性和安全性。方法:本文通过具有健脾除湿、疏利少阳作用的慢肾安颗粒与肾炎平颗粒进行随机对照临床研究，初步探讨健脾除湿、疏利少阳法治疗慢性肾小球肾炎的有效性和安全性。结果：FAS分析结果表明,慢肾安颗粒试验组对慢性肾小球肾炎的临床控制率为14.0%, 控显率为36.4%,总有效率为65.5%；肾炎平颗粒对照组分别为20.0%、40.0%和70.0%，组间比较，差异无统计学意义。慢肾安颗粒试验组对患者脾虚湿盛的愈显率为36.5%, 总有效率为84.5%；肾炎平颗粒对照组分别为25.0%和68.4%，组间比较，差异无统计学意义。慢肾安颗粒试验组对患者蛋白尿的临床控制率为15.5%,控显率为41.4%，总有效率为60.3%；肾炎平颗粒对照组分别为25.0%、36.8%和68.4%，组间比较，差异无统计学意义。慢肾安颗粒试验组对患者血尿的临床控制率为34.1%,控显率为34.1%，总有效率为43.2%；肾炎平颗粒对照组分别为45.5%、45.5%和54.5%，组间比较，差异无统计学意义。两组治疗前后均进行了三大常规、肝功、心电图及电解质检查，均未发现与试验药物有关的异常改变，试验过程中未见明显不良反应，安全性较好。结论：健脾除湿、疏利少阳法是治疗慢性肾小球肾炎的有效治法之一,能较好的改善患者的临床症状，减少蛋白尿和血尿，稳定肾功能。关键词：健脾除湿疏利少阳慢性肾小球肾炎中医药疗法临床研究ABSTRACTSObjective:TostudytheeffectandsafetyofTCMtherapy(namedbyreiforcethespleen andtransformingdampness、smoothingandregulatingshao-yang)onchronic glomerulonephritis.Methods:TostudytheeffectandsafetyofTCMtherapy(namedbyreiforcethespleenand transformingdampness、smoothingandregulatingshao-yang)onchronic glomerulonephritis.ThestudyadoptsclinicmethodofrandomandcomparisonthroughManshenangranuleandShenyanpinggranulewhichhavethefunctionofreiforcethe spleen and transforming dampness、smoothing and regulating shao-yang.hatconformtotheconditioncanbeselected.Giveingthepationtsmedicineaccordingto sequenceofpatientscomingtohospitalandarrangethepationttothegroupofcureorthe groupofcomparison.TheresultofFASshows:inthegroupofchronicglomerulonephritis thatistreated,therateofcompleteremissionis14.0%,cureandgreatefficiencyis 36.4%,totalefficiencyis65.5%.inthegroupofcomparison,therateofcompleteremission is20.0%,cureandgreatefficiencyis40.0%,totalefficiencyis70.0%.Thegroupcomparison indicates:thecontrasthasnostatisticallysignificant.Inthegroupofdampabundancedue tosplenicastheniathatistreated,therateofcureandgreatefficiencyis36.5%,total efficiencyis84.5%,inthegroupofcomparison,therateofcureandgreatefficiencyis 25.0%,totalefficiencyis68.4%.Thegroupcomparisonindicates:thecontrasthasno statisticallysignificant.inthegroupofurineproteinthatistreated,therateofcomplete remiss