基于dna键合的不对称n,n-双取代草酰胺双核铜(ⅱ)配合物的合成、结构及抗癌活性研究-synthesis, structure and anticancer activity of asymmetric n, n - disubstituted oxamide dinuclear copper ( ⅱ ) complex based on dna bonding.docxVIP

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基于dna键合的不对称n,n-双取代草酰胺双核铜(ⅱ)配合物的合成、结构及抗癌活性研究-synthesis, structure and anticancer activity of asymmetric n, n - disubstituted oxamide dinuclear copper ( ⅱ ) complex based on dna bonding.docx

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基于dna键合的不对称n,n-双取代草酰胺双核铜(ⅱ)配合物的合成、结构及抗癌活性研究-synthesis, structure and anticancer activity of asymmetric n, n - disubstituted oxamide dinuclear copper ( ⅱ ) complex based on dna bonding

Synthesis, Structures and dict://key.0895DFE8DB67F9409DB285590D870EDD/anticancer%20activityAnticancer activity of N,N’-disubstituted Oxamides-bridged Binuclear Copper(Ⅱ) Complexes based onDNA-binding Properties AbstractCopper, one of 14 kinds of essential trace elements for human, acts an important role in constituting human body and regulating dict://key.0895DFE8DB67F9409DB285590D870EDD/physical%20functionphysical function. In drug design and syhthesis, the effective utilization of copper has a positive impact on the development of new drugs and the improvement of drug effect. Affected by the application of cisplatin, carboplatin and other platinum compounds in anticancer field, metal drugs, especially those targeting at the DNA molecules in cancer cells, have become the focus of anticancer drug design, but so far, there are few drugs has entered clinical trials. In order to find anticancer drugs with low toxicity and high efficiency, this thesis has used copper as the central atom of metal complexes, chosen two N,N’-disubstitutedoxamides as the ligands, dict://key.0895DFE8DB67F9409DB285590D870EDD/synthesissynthesised a series of oximide-bridged polynuclear copper(Ⅱ) complexes,and obtained five dict://key.0895DFE8DB67F9409DB285590D870EDD/monocrystalmonocrystals;at the same time, the DNA-binding properties and citotoxities of the monocrystals have been studied systematically. The detailed contents are as followed:Synthesis and structures of polynuclear complexes: five complexes were synthesized and characterizedbychoosingN-(2-hydroxyphenyl)-N’-(3-aminopropyl)oxamide(H3papo)and N-(5-chloro-2-hydroxyphenyl)-N-[3-(methylamino)propyl]oxalamide (H3chmpoxd) as the bridging ligands, including[Cu2(papo)(phen)(H2O)] (ClO4)·2H2O (1), [Cu2(papo)(Me2bpy)(CH3CH2OH)](pic) (2), [Cu2(chmpoxd)(H2O)(bpy)]ClO4·H2O(3), [Cu2(chmpoxd)(H2O)(bpy)]Cl·3H2O (4) , [Cu2(chm- poxd)(H2O)(bpy)]NO3·CH3CN (5). Their structures have been characterized by elemental analyses, IR and single-crystal X-r