蒿芩清胆汤对h.pylori感染小鼠慢性胃炎nf-κbp65 il-8表达影响的实验分析-experimental analysis of the effect of haoqin qingdan decoction on the expression of nf - κ bp65 il - 8 in h pylori infected mice.docx

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2018-05-28 发布于上海
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蒿芩清胆汤对h.pylori感染小鼠慢性胃炎nf-κbp65 il-8表达影响的实验分析-experimental analysis of the effect of haoqin qingdan decoction on the expression of nf - κ bp65 il - 8 in h pylori infected mice.docx

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蒿芩清胆汤对h.pylori感染小鼠慢性胃炎nf-κbp65 il-8表达影响的实验分析-experimental analysis of the effect of haoqin qingdan decoction on the expression of nf - κ bp65 il - 8 in h pylori infected mice

Abstract【Objective】ThispaperaimstoexplorethetherapeuticmechanismofHpassociatedgastritisbyHaoqinQingdandecoctiononexpressionofNF-κBP65、IL-8inBalb/cmicegastritismodecausedbyH.pyloriinfection.【Method】Hpstandardstrains(SS1)brinellbrothliquidwasusedtoestablishtheresearchmodel,andthemodelmicewererandomlydividedintofourgroups(modelgroup,livzonweisanliangroup,HaoqinQindandecoctionhigh-dosegroup,middledosegroup)with10ineachoneafterthecompletionofestablishingtheresearchmodel.Aftertheendofexperiment,allmicewerekilled,andthepathologicalhistologychangeofeachgroupwasobservedbythemicroscope,andenzyme-linkedimmunoassayandimmunohistochemicalmethodwereappliedrespectivelytodetectexpressionofIL-8inserum,IL-8andNF-κBP65ingastricmucosatissueofmiceineachgroup.【Results】SerumIL-8:eachtreatedgroupweresignificantlylowerthanthemodelgrouponIL-8expressioninmiceserum(P0.05),amongwhich,HaoqinQingdandecoctionmiddledosegroupandlivzonweisanliangroupappearthebesttherapeuticeffect（P0.05）.MiddledosegroupandhighdosegroupwithHaoqinQingdandecoctionweresignificantlydifferent(P0.05)inexpressionofserumIL-8.MicegastricmucosalIL-8:eachtreatedgroupweresignificantlylowerthanthemodelgrouponIL-8expressioninmicegastricmucosal(P0.05),amongthem,livzonweisanliangroupwassignificantdifferent(P0.05)fromhighandmiddledosegroupwithHaoqinQingdandecoction.3.MicegastricmucosalNF-κBP65：eachtreatedgroupweresignificantlylowerthanthemodelgrouponNF-κBP65expressioninmicegastricmucosal(P0.05),amongthem,livzonweisanliangroupwassignificantdifferent(P0.05)fromhighandmiddledosegroupwithHaoqinQingdandecoction.4Micegastrichistopathology:Comparedwithmodelgroup,alltreatmentgroupsweresignificantonreductionofgastricmucosalinflammationareaandaverageblacklevel(P0.05).Onthereductionoftheinflammationareasofgastricmucosa,highdosegroupwithHaoqinQingdandecoctionandthelivzonweisanliangroupappearsimilareffect（P0.05）,whilehighdosegroupandmiddledosegroupwithHaoqinQingdandecoctionweresignificantdifferent(P0.05).【Conclusion】HaoqinQingdandecoctioncansignific