红细胞外泌体为载体靶向肿瘤药物投递分析-targeted tumor drug delivery analysis using erythrocyte exocrine as carrier.docx

目录第一章绪论.........................................................................................................11.1引言.............................................................................................................11.2癌症化疗的研究现状..................................................................................21.2.1化疗存在的问题................................................................................21.2.2纳米药物载体....................................................................................31.3外泌体.........................................................................................................41.3.1外泌体的生物来源............................................................................41.3.2外泌体的结构和组成........................................................................51.3.3外泌体的功能....................................................................................61.3.4外泌体的分离提纯方法....................................................................71.3.5外泌体作为载体的可能性及存在问题.............................................71.4超顺磁性纳米粒子在癌症诊断与治疗方面的研究进展............................91.4.1超顺磁性纳米粒子在癌症诊断方面的应用.....................................91.4.2超顺磁性纳米粒子在癌症治疗方面的应用.....................................91.4.3超顺磁性纳米粒子在分离方面的应用...........................................101.5阿霉素简介...............................................................................................101.6本论文工作的提出...................................................................................12第二章超顺磁性纳米粒子分离外泌体及表征........................................132.1引言...........................................................................................................132.2实验部分...................................................................................................142.2.1仪器和试剂.....................................................................................142.2.2超顺磁性纳米粒子分离外泌体及其表征.......................................152.3结果与讨论.........................................................