irf2基因在干扰素γ影响胰腺腺泡细胞炎症反应与自噬活性中的作用研究-study on the role of irf 2 gene in the influence of interferon-γ on inflammatory response and autophagy activity of pancreatic acinar cells.docx

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irf2基因在干扰素γ影响胰腺腺泡细胞炎症反应与自噬活性中的作用研究-study on the role of irf 2 gene in the influence of interferon-γ on inflammatory response and autophagy activity of pancreatic acinar cells.docx

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irf2基因在干扰素γ影响胰腺腺泡细胞炎症反应与自噬活性中的作用研究-study on the role of irf 2 gene in the influence of interferon-γ on inflammatory response and autophagy activity of pancreatic acinar cells

目录中文摘要·················································································································1ABSTRACT3前言·················································································································61第一部分干扰素-γ对AR42J细胞炎症反应与凋亡的影响材料和方法·················································································································13结果·················································································································17讨论·················································································································182第二部分干扰素-γ对AR42J细胞自噬作用的影响材料和方法·················································································································21结果·················································································································23讨论·················································································································263第三部分IRF-2基因对自噬机制的调控作用及其对AR42J细胞炎症反应的影响材料和方法·················································································································28结果·················································································································31讨论·················································································································34参考文献···············································································································36综述·················································································································44在读期间发表论文和参加科研工作情况··································································73致谢·····························································································································743IRF-2基因在干扰素-γ影响胰腺腺泡细胞炎症反应与自噬活性中的作用研究摘要目的（1）观察IFN-γ对AR42J细胞急性胰腺炎过程中细胞上清IL-1、IL-6、TNF-α及AMS等炎症因子的影响，以及凋亡与自噬作用的改变；并探讨自噬改变对AR42J细胞炎症反应的影响及IRF-2基因的改变，初步探讨自噬机