结直肠癌个体筛查调查及结直肠癌差异表达基因mmp23b的表达研究-investigation on individual screening of colorectal cancer and study on expression of mmp 23 b in colorectal cancer differential expression gene.docx

MMP23b 是结直肠肿瘤的危险因素，且与肿瘤分期相关。高血浆 MMP23b 浓度和罹患高血压病是结直肠肿瘤的预测因子，MMP23b 对结直肠癌的诊断价值需在普通人群中加 以探讨。关键词：结直肠癌，个体筛查，横断面研究，基质金属蛋白酶 23b，表达，病例对照 研究AbstractColorectal cancer (CRC) is one of the most common cancers in human. The prevalence of CRC ranks the third leading place among all malignant tumors worldwide. Early CRC is usually asymptomatic or with atypical symptoms, so it is easily ignored and delayed in treatment. Statistics showed about 70% patients were in middle or terminal cancer stage as they were diagnosed. Screening for CRC is an important method for early cancer diagnosis and the reduction of cancer mortality, but the effectiveness of screening depends on the compliance of screening population. Low screening compliance, not only existed in the screening programs of Western countries, but also found in the community-based natural population screening in China. The selection of a reasonable screening model is the foundation for effective screening, and a more effective diagnostic marker will enhance the compliance of screening.Many factors could affect the screening compliance. A recent systematic review, which intended to summarize the reasons that patients cited as influencing factors in qualitative researches, showed that a lack of the knowledge about CRC and screening methods, screening costs, screening embarrassment, a fear of screening complications or discomfort, barriers of screening implementation, a lack of communication with physicians, a lack of awareness in cancer and screening were the most important factors and causes for low compliant rate. Beyond the reasons mentioned above, other researchers pointed that a reasonable choice of screening model would not only affect the screening compliance but also influence the feasibility of screening.Currently, our domestic screening is mainly carried out by a small number of Units who had the capacity of screening. The screening model adopted is natural population based. Few of researchers notice the effectiveness