抗氧化指标水平变化sod gsh mda在copd治疗过程中临床意义-clinical significance of sod gsh mda in the treatment of copd.docxVIP
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抗氧化指标水平变化sod gsh mda在copd治疗过程中临床意义-clinical significance of sod gsh mda in the treatment of copd
ABSTRACTChronicobstructivepulmonarydisease(COPD)isacommonchronicrespiratorydiseasewithhighmorbidityandhighmortality.Theacutephase(AECOPD)repeatedepisodesisthemainreasonforprogressivedeclinethelungfunctionandincreasedmortalityinpatientswithCOPD.ThehighincidenceofCOPDpatientsnotonlybroughttolifedangerandeconomicburden,butalsoaseriouspublichealthproblemtobringaheavyeconomicburdenonsociety.ThesensitivedetectionindicatorsofAECOPDandstablephasecanmakethehealthworkersdetectearlylesionsinpatientsandchangethedosingregimenintimethatreducetheinjurytothepatientswithAECOPD,reducethefinancialburdenonpatientsandsociety.ToprovidetheoreticalbasisforearlydiagnosisofAECOPD,theexperimentexplorethechangesofantioxidationsystemlevel(SOD,GSH,MDA)oftheCOPDduringthetreatment(acuteperiodandstableperiod)significance,Atthesametime,thejointdetectionofplatelethematocrit(PCT)levelandchangesinWBC,andprovideatheoreticalbasisfortheearlydiagnosisofCOPDandevaluationofcurativeeffect.Method:Thestudyselectour80casesoftheAECOPDpatients(ageabove40)admittedRespiratoryMedicineofourhospitalaccordingtoGuide2011revisionofdiagnosisandtreatmentofchronicobstructivepulmonarydiseaseformulatebyChinesemedicalassociationrespiratoryneurology.Andselectionof30casesofhealthypeople(ageabove40)ascontrolgroup.ControlgrouptakenonthemorningfastingvenousbloodoftheexaminationdaytodetectPCTandWBCwithwholebloodanddetectantioxidantindexwithserum.COPDpatientsinhospitaltakeafastingvenousbloodinthemorningoffirstday(acuteaggravatingperiod),andtreatmentof5,10,14days(remission)todetectPCTandWBCwithwholebloodanddetectantioxidantindexwithserum.ForeachgrouppatientswithPulmonaryfunctiontests,temperaturemeasurement,recordingchangesinsputumvolume,dyspneareliefofrecords,diseaseprogressionwasobservedinpatients.CompareAECOPDandCOPDremissionofvariousindicatorsofchange,toexplorewhethertheycanbeusedtodetectCOPDacuteandremission.Comparingtheindicatorschangeandrecoveryamongthepatientswithallages,smokersandnon-smokers,workenvironmentalexposuretosmokeando
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