口服避孕药预处理在ivf长方案中的临床价值分析-clinical value analysis of oral contraceptives pretreatment in ivf long program.docx

华中科技大学硕士学位论文 华 中 科 技 大 学 硕 士 学 位 论 文 5 5 were divided into two groups according to the pretreatment with OC or not: Group OC, prior oral contraceptive and the control, no prior oral contraceptive. Result: The total does of GnRHa and Gn, the start day of ovary stimulation and the duration of stimulation were no differences between the two groups (P＞0.05). The number of retrieved oocytes, MⅡoocytes and total embryos were not significantly different between the two groups, neither were the rates of fertilization, cleavage and pregnancy, the incidence of ovarian cyst, and the cycle’s cancellation rate for poor ovarian response (P＞ 0.05). But the levels of serum E2 before the ovarian stimulation in Group OC were significant lower than in the control. On the day of HCG injection, there were significant higher serum E2 levels and thinner endometrium in Group OC (P＜0.001). In addition, the cancelling rate of fresh embryo-transfers caused by high risks of ovarian hyperstimulation syndrome (OHSS) (＞20 oocytes and correlative clinical symptom) in Group OC was significantly higher than in the control(P＜0.05). The two groups were respectively divided on the basis of age into 4 layers of ≤25 years, 25~30 years, 30~35 years, ＞35 years(The constituent ratio is no difference between the two groups, χ2=3.006，P=0.391), and the variables of every layer between the two groups were analyzed. The comparison outcomes in the other three layers under 35 years between the 2 groups were similar to the whole subjects, But the serum LH levels of women ＞35 in group OC were much lower than that of control after suppression (P ＜0.05), and they needed more dose of Gn (P＜ 0.001) which probably caused by deeper suppressive. The serum E2 levels of women ＞35 years on the day of HCG injection were lower than younger women but there was no significant difference in these older women between the two groups(P＞0.05). Conclusion: Pretreatment with OC prior to pituitary suppression with Gn