高尿酸血症患者血浆尿酸水平与颈动脉内中膜厚度相关性研究.docVIP

高尿酸血症患者血浆尿酸水平与颈动脉内中膜厚度相关性研究 　　[摘要] 目的 探讨血浆尿酸水平与颈动脉内中膜厚度的关系。 方法 收集高尿酸血症患者78例，同时收集40例血浆尿酸水平正常且基线资料与高尿酸血症患者相匹配的研究对象作为对照组。采用超声检测双侧颈总动脉内中膜厚度。高尿酸血症患者予碳酸氢钠（1.0 g，tid）和别嘌呤醇（100 mg，bid）口服治疗，同时给予控制血压/血糖、调节血脂和抗血小板等心脑血管疾病一级预防，随访6个月按上述方法重复测量颈动脉内中膜厚度。 结果 （1）与对照组相比，高尿酸组人群血浆尿酸水平明显升高，差别具有统计学意义（P ＜ 0.05）；（2）与对照组相比，入院时，高尿酸组人群颈动脉内中膜厚度明显增大（P ＜ 0.05）；治疗6个月后，血浆尿酸水平明显降低[（418±20） μmol/L vs （587±46） μmol/L，P ＜ 0.05]，且高尿酸组颈动脉内中膜厚度明显低于入院时[（0.84±0.06） mm vs （0.96±0.04） mm，P ＜ 0.05]。Pearson相关分析提示，血浆尿酸水平与颈动脉内中膜厚度呈正相关，相关系数r = 0.864（P ＜ 0.05）。 结论 血浆尿酸水平与颈动脉内中膜厚度呈正相关，检测血尿酸水平可以反映颈动脉硬化程度。 　　[关键词] 尿酸；颈动脉内中膜厚度；相关性；高尿酸血症 　　[中图分类号] R446.1 [文献标识码] A [文章编号] 1674-4721（2012）03（a）-0005-03 　　 　　Correlation research of serum level of uric acid with carotid intima-media thickness in patients with hyperuricemia 　　ZHAO Juquan XIE Bing YUAN Chengwei 　　Clinical Laboratory of Guicheng Hospital of Nanhai District in Guangdong Province, Foshan 528200, China 　　[Abstract] Objective To investigate the correlation of serum level of uric acid (UA) with carotid intima-media thickness (CIMT). Methods Seventy eight cases of patients with higher serum level of UA and 40 cases with normal serum level of UA (control group) whose basic information was matched with patients of the higher serum level of UA were enrolled. Bilateral CMIT of common carotid artery were detected by ultrasound. Patients with higher serum level of UA were prescribed with sodium bicarbonate (1.0 g, tid) and allopurinol (100 mg, bid) orally, and were also given with first prevention of cardiac-cerebra vascular diseases by controlling of blood pressure and serum level of glucose, regulation of lipid and anti-platelet. 6 months later, CIMT was detected as above again. Results (1) Compared to the control group, serum level of UA was significantly higher in patients with higher serum level of UA (P 　　1.2 研究方法 　　采用7.5 MHz线阵分析探头，对所有入选者进行双侧颈总动脉内中膜厚度测量，颈动脉内中膜厚度于颈总动脉分叉近端1 cm 处后壁或颈动脉内中膜厚度最厚处进行测量，纵向超声显像可表现为由相对较低回声分隔的2 条平行亮线，2线间距离即为颈动脉内中膜厚度，测量2次颈