壮骨强筋法治疗骨质疏松症疗效分析.docVIP

壮骨强筋法治疗骨质疏松症疗效分析 　　[摘要] 目的：观察壮骨强筋法治疗骨质疏松症的效果。方法：将60例骨质疏松症患者随机分为治疗组和对照组，每组各30例。治疗组口服自拟壮骨强筋方，对照组口服阿法骨化醇软胶囊，观察比较两组治疗后的临床总体疗效及骨密度变化情况。结果：治疗组总有效率为90.0％，对照组为73.3％。在临床总体疗效和骨密度测定方面，治疗组较对照组明显改善，差异有统计学意义(P 　　[关键词] 壮骨强筋法；骨质疏松症；疗效；分析 　　[中图分类号] R2 [文献标识码] B [文章编号] 1674-4721（2011）12（b）-108-02 　　 　　Efficacy analysis of strengthening bones and tendons in the treatment of osteoporosis 　　LI Min1, ZHANG Qicheng2 　　1.Department of TCM Orthopaedics, Guilin Hospital of Chaoyang District in Changchun City, Jilin Province, Changchun 130021, China; 2. Department of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Jilin Province, Changchun 130041, China 　　[Abstract] Objective: To observe the efficacy of strengthening bones and tendons in the treatment of osteoporosis. Methods: Sixty patients with osteoporosis were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was given self-made Zhuangguqiangjin decoction, the control group was given Alfacalcidol soft Capsules. The total clinical efficacy and changes of bone mineral density after treatment between the two groups were observed and compared. Results: The total effective rate was 90.0% in the treatment group and 73.3% in the control group. The total clinical efficacy and the measurement of bone mineral density in the treatment group were much better than the control group, the differences were significant (P0.05），具有可比性。 　　1.2 纳入标准 　　参照《中药新药临床研究的指导原则》骨质疏松症的诊断标准制定[1]：①腰脊疼痛明显，逐渐加重，脊椎常有后凸畸形；②X线表现骨质普遍稀疏，以脊椎、骨盆、股骨上端明显；③骨密度测定，阳性（采用双能X线骨密度仪测定，骨密度峰值减少25%以上）；④中医症候为肝肾不足证，腰脊疼痛，眩晕耳鸣，酸软少力，不能持重，关节僵硬，舌质或偏红或淡，苔薄，脉沉细。 　　1.3 排除标准 　　具有或合并其他影响骨代谢的疾病，如骨肿瘤、骨软化症的患者；使用影响骨代谢药物的患者；合并有心、肝、肾等严重疾病及精神病患者；不能坚持治疗或无法判定疗效的患者。 　　1.4 治疗方法 　　治疗组口服自拟壮骨强筋的中药汤剂，具体药物组成：淫羊藿、黄精、熟地、菟丝子、杜仲、桑寄生、枸杞子、赤芍、丹参、鸡血藤、当归、茯苓、炒白术、黄芪、甘草。上药水煎服，每日1剂，分2次温服。对照组口服阿法骨化醇软胶囊（昆明贝克诺顿生产，国药准字每次 1粒，每日2次。连续用药2个月为1个疗程。治疗期间停服其他中药及本病有关的西药，以确保观察数据准确性。 　　1.5 疗效评定标准 　　参照《中药新药临床研究的指导原则》治疗骨质疏松症的疗效判定标准制定。显效：中医临床症状、体征明显