断血流分散片的制备工艺研究.docVIP

毕业设计(论文) 课 题 名 称 断血流分散片的制备 学 生 姓 名 学 号 系、年级专业 指 导 教 师 职 称 讲 师 2012 年 月 日 1.15，加1.7倍量的乙醇提取，上清液，减压浓缩成稠膏，干燥，所得干膏粉经优选处方，以崩解时间作考察指标，采用直观分析确定处方的最佳用量，得成型工艺。结果 按优选处方制备的分散片可在3min内完全崩解并且全部通过2号筛，符合《中华人民共和国药典》对分散片的要求，其体内吸收明显优于普通片。混合药粉经制粒后颗粒的休止角减少，流动性增大。压制的片剂符合分散片的特征。结论 处方工艺稳定，重现性好，成品收率高，适合工业化生产。故所优选的成型工艺是可行的。 关键词 断血流；分散片；制备工艺；处方工艺；休止角；临界相对湿度；醉鱼草皂苷IV b The preparation of dispersible tablet duan xue liu process research Abstract Objective For the preparation of dispersible tablet Duan xue liu process for the blood flow of dispersible tablet broken research theory provides the basis. Methods Take Chinese traditional medicine Duan xue liu thick section, add 8-10 times water decoction twice, filtration, filtrate reduced pressure concentration to the relative density of 1.15, and 1.7 times the amount of ethanol, clear liquid on, the reduced pressure concentration into thick cream, dry, dry paste by optimizing the powder prescription, with complete index for disintegrating time, by using object analysis to identify the best prescription dosage, molding process. Results According to the optimization of the preparation of prescription dispersible tablet available in 3 min disintegrating and entirely within all through the NO. 2 sieve, accord with the pharmacopoeia of the Peoples Republic of scattered to the demand, the body absorb significantly better than ordinary piece. Mixing angle of repose of powder with granulated particles after reduction,　increased liquidity. Pressed tablets meet dispersible Tablet features. Conclusion Formulation and process stability, reproducibility, and high yield of finished products, suitable for industrial production. The optimization of forming process is feasible. Key words: duan xue liu; dispersing tablet; preparation technology; formula and preparation technique; slope of repose; critical relative moisture; buddlejasaponins