消化文章节(14).pdf

Gastroenterology Malabsorption Malabsorption syndrome Malabsorption syndrome Causes: Causes: failed process ofthe intestinal absorption of nutrients failed process ofthe intestinal absorption of nutrients Consequences: Consequences: symptoms ofmalnutritive state – lack of bodycomponents symptoms ofmalnutritive state – lack of bodycomponents Pathophysiology: Pathophysiology: – Loss ofintestinal surface – Loss ofintestinal surface Mucosal damage (celiac sprue Mucosal damage (celiac sprue Shortened bowel (bowel resection Shortened bowel (bowel resection – Impaired intestinal intraluminal digestion (lack ofmucosal – Impaired intestinal intraluminal digestion (lack ofmucosal enzymes enzymes – Impaired vascular andlymphatic transport ofabsorbed – Impaired vascular andlymphatic transport ofabsorbed nutrients (arterial or lymphatic obstruction nutrients (arterial or lymphatic obstruction The absorptive surface The absorptive surface Surface area amplification Surface area amplification – Simple cylinder (≈2cm – Simple cylinder (≈2cm 3x 3x – Folded cylinder (≈1cm – Folded cylinder (≈1cm 10x 10x 600x 600x – Villi (≈0.2mm – Villi (≈0.2mm 20x 20x – Microvilli (≈2m – Microvilli (≈2m Malabsorption Malabsorption LABORATORY RESULTS LABORATORY RESULTS TEST MUCOSAL IMPAIRED DIGESTION LYMPHATI TEST MUCOSAL IMPAIRED DIGESTION LYMPHATI DISEASE Pancreatic Bact.Ovgr. OBSTRUCT.