改良老年疾病累计评分表在老年食管癌患者中应用-application of improve accumulated score table of senile disease in elderly esophageal cancer patients.docxVIP

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改良老年疾病累计评分表在老年食管癌患者中应用-application of improve accumulated score table of senile disease in elderly esophageal cancer patients.docx

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改良老年疾病累计评分表在老年食管癌患者中应用-application of improve accumulated score table of senile disease in elderly esophageal cancer patients

group, the ages ranged form 65 to 84 (mean age=72);45 patients were enrolled in the control group, the ages ranged form 35 to 64 (mean age=56).41 patients had comorbidities in the elderly group (41/57), while 21 in the control group (21/45).There was a significant difference of the prevalence of comorbidity between the two groups (P0.05).In two groups of comorbidities, a significant difference was found in hypertension( P=0. 002) and chronic respiratory diseases( P=0. 023) but not t he ot her s(P0.05). In the elderly group, the frequent comorbidities were hypertension (24 cases, 42.11%), and chronic respiratory diseases (16 cases, 28.07%), and in the control group, the frequent comorbidities were digestive diseases such as chronic gastritis (11 cases, 24.44%), cholecystitis and gallbladder stones (n=7cases, 15.56%). MCIRS-G score (z = 5.140, P = 0.000) and the number of systems affected by the complications of the elderly group were higher than the control group. Basedon MCIRS-G score and age, 90 patients with chemotherapy were divided into 14，15，16，17and ≥ 18 points. Analysis showed that in the elderly group, with the MCIRS-G scores increased, the blood system toxicity (P= 0.016), liver and kidney function impairment (P=0.034), fatigue (P=0.037) in the different point have a significantdifferent incidence, but the incidence of digestive system toxicity (P = 1.000) did not show significant differences. Trend test in the five points of elderly group,Ⅱ ~ Ⅲ grade leucopenia rates were 0,16.7%, 60%, 69.2%, 80% (P = 0.001), liver and kidneydysfunction rates were 0,0,20% , 46.2%, 60% (P = 0.002), the incidence of fatigue were 0,16.7%, 30%, 38.5%, 73.3% (P = 0.002).With the increase of MCIRS-G score, the incidence of leucopenia, liver and kidney dysfunction and fatigue increasing. However, There was no change in the incidence of toxicity when stratified by age or KPS. MCIRS-G score was positively correlated with age (r = 0.821, P = 0.000), andwas little correlated with KPS